Evaluating micro-optical coherence tomography as a feasible imaging tool for pancreatic disease diagnosis

Xiaojun Yu, Qianshan Ding, Chi Hu, Ganggang Mu, Yunchao Deng, Yuemei Luo, Zhaohui Yuan, Honggang Yu, Linbo Liu

科研成果: 期刊稿件文章同行评审

12 引用 (Scopus)

摘要

Pancreatic cancer is one of the leading causes of cancer mortality worldwide due to the lack of reliable tools for early diagnosis of this cancer. In this study, we evaluated the feasibility of micro-optical coherence tomography (μ OCT) as an imaging tool for the diagnosis of pancreatic cancers. Specifically, we constructed a μ OCT device that achieves a resolution of 1.67pm 0.01, μm and 1.79pm 0.01, μm in axial and lateral directions, respectively, and acquired three-dimensional μ OCT images of mouse, rat, and human pancreatic specimens ex vivo. We compared the results of μ OCT with those of the corresponding histology. In μ OCT images of normal pancreatic specimens, the detailed cellular and subcellular-level pancreatic microstructures, e.g., the islet of Langerhans (IL), IL cell nuclei, blood vessels, and serous acini, could be clearly resolved in different cases. To the best of our knowledge, this study is the first to demonstrate that the cellular and subcellular structures of pancreatic tissues were identified using OCT. More importantly, we showed that these normal cellular-level structures were lost in μ OCT images of cancerous specimens, demonstrating the feasibility of differentiating malignant lesions from normal tissues using μ OCT. Moving forward, the development of an intraoperative imaging device may realize optical biopsies in vivo or real-time cellular-resolution examination of specimens from needle aspiration biopsies.

源语言英语
文章编号8338388
期刊IEEE Journal of Selected Topics in Quantum Electronics
25
1
DOI
出版状态已出版 - 1 1月 2019

指纹

探究 'Evaluating micro-optical coherence tomography as a feasible imaging tool for pancreatic disease diagnosis' 的科研主题。它们共同构成独一无二的指纹。

引用此