TY - GEN
T1 - Epithelial tissue abnormity analysis based on single backscattering polarimetric spectrum
AU - Zhao, Yongqiang
AU - Wei, Peifeng
PY - 2009
Y1 - 2009
N2 - The pathological changes of skin will change the tissue's birefringence and structure, which can be measured by the polarization and spectral changes of tissue's scattering light. Light-scattering polarimetric spectrum is an effective tool to measure these features for quantitative pathology analysis. In this paper, a theoretical model of single backscattering spectra based on Mie theory is established, to describe the polarized light scattering spectroscopy for a two-layered scattering medium. To test the utility of this model, an epithelial tissue polarimetric spectral imaging system is proposed, then human frostbite sample is imaged using the system. Proposed model is used to acquire the morphological parameters closely relating to the abnormality of biological tissue, including the mean diameter, size distribution and relative refractive index. Experimental results demonstrated the potentials of the proposed techniques in skin pathological diagnosis and treatment evaluation.
AB - The pathological changes of skin will change the tissue's birefringence and structure, which can be measured by the polarization and spectral changes of tissue's scattering light. Light-scattering polarimetric spectrum is an effective tool to measure these features for quantitative pathology analysis. In this paper, a theoretical model of single backscattering spectra based on Mie theory is established, to describe the polarized light scattering spectroscopy for a two-layered scattering medium. To test the utility of this model, an epithelial tissue polarimetric spectral imaging system is proposed, then human frostbite sample is imaged using the system. Proposed model is used to acquire the morphological parameters closely relating to the abnormality of biological tissue, including the mean diameter, size distribution and relative refractive index. Experimental results demonstrated the potentials of the proposed techniques in skin pathological diagnosis and treatment evaluation.
KW - Abnormity analysis
KW - Backscattering polarimetric spectrum
KW - Mie theory
UR - http://www.scopus.com/inward/record.url?scp=74349110662&partnerID=8YFLogxK
U2 - 10.1109/BMEI.2009.5305339
DO - 10.1109/BMEI.2009.5305339
M3 - 会议稿件
AN - SCOPUS:74349110662
SN - 9781424441341
T3 - Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
BT - Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
T2 - 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
Y2 - 17 October 2009 through 19 October 2009
ER -