Enhancing signals of microfluidic impedance cytometry through optimization of microelectrode array

Chenyang Zhou, Hailong Shen, Huicheng Feng, Zhibin Yan, Bowen Ji, Xichen Yuan, Ruirong Zhang, Honglong Chang

科研成果: 期刊稿件文章同行评审

5 引用 (Scopus)

摘要

Microfluidic impedance cytometry shows a great value in biomedical diagnosis. However, the crosstalk between neighboring microelectrodes strongly weakens the impedance signal. Hereby, we demonstrate a novel microfluidic impedance cytometer consisted of sensing electrodes and ground electrodes (GNDs). The simulation reveals a signal enhancement by more than five times with GNDs compared to that without ones. We also found that the linear correlation between the impedance at a high frequency and that at a low frequency varies as microparticle size changes, which can be used for microparticle classification. The study can help with microelectrode optimization and signal processing for microfluidic impedance analysis.

源语言英语
页(从-至)2156-2164
页数9
期刊Electrophoresis
43
21-22
DOI
出版状态已出版 - 11月 2022

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