Degradable Semiconducting Oligomer Amphiphile for Ratiometric Photoacoustic Imaging of Hypochlorite

Chao Yin, Xu Zhen, Quli Fan, Wei Huang, Kanyi Pu

科研成果: 期刊稿件文章同行评审

214 引用 (Scopus)

摘要

Upregulation of highly reactive oxygen species (ROS) such as hypochlorite (ClO-) is associated with many pathological conditions including cardiovascular diseases, neuron degeneration, lung injury, and cancer. However, real-time imaging of ClO- is limited to the probes generally relying on fluorescence with shallow tissue-penetration depth. We here propose a self-assembly approach to develop activatable and degradable photoacoustic (PA) nanoprobes for in vivo imaging of ClO-. A near-infrared absorbing amphiphilic oligomer is synthesized to undergo degradation in the presence of a specific ROS (ClO-), which integrates a π-conjugated but ClO- oxidizable backbone with hydrophilic PEG side chains. This molecular architecture allows the oligomer to serve as a degradable nanocarrier to encapsulate the ROS-inert dye and self-assemble into structurally stable nanoparticles through both π-π stacking and hydrophobic interactions. The self-assembled nanoprobe exhibits sensitive and specific ratiometric PA signals toward ClO-, permitting ratiometric PA imaging of ClO- in the tumor of living mice.

源语言英语
页(从-至)4174-4182
页数9
期刊ACS Nano
11
4
DOI
出版状态已出版 - 25 4月 2017
已对外发布

指纹

探究 'Degradable Semiconducting Oligomer Amphiphile for Ratiometric Photoacoustic Imaging of Hypochlorite' 的科研主题。它们共同构成独一无二的指纹。

引用此