Constructing fiber atlases for functional ROIs via fMRI-guided DTI image registration

Tuo Zhang, Lei Guo, Hanbo Chen, Xintao Hu, Kaiming Li, Tianming Liu

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

Quantitative mapping of the relationship between brain structure and function has emerged as an active research field in order to answer the question of whether brain structure can predict its function. In the literature, it is widely believed that a brain region's structural connectivity pattern largely determines the function it performs. Based on this premise, we used multimodal diffusion tensor imaging (DTI) and task-based fMRI data to perform fMRI-guided DTI image registration and built structural fiber atlases for functional brain Regions of Interests (ROIs). First, we used workingmemorytask-based fMRI-derived ROIs as the functional constraint to register DTI images into a template via an energy minimization procedure. Then, the regularity and variability of the warped white matter fibers for each ROI was quantitatively assessed, and it turns out that structural connection patterns for corresponding functional ROIs across different subjects are quite consistent. Therefore, we constructed the white matter fiber atlases for these functional ROIs, which can be used as intrinsic attributes of those ROIs for quantitative representation of cortical architecture. Our results provided evidence that there is deep-rooted regularity of the common human brain architecture and that structural connectivity is strongly correlated with brain function.

源语言英语
主期刊名Multimodal Brain Image Analysis - Second International Workshop, MBIA 2012, Held in Conjunction with MICCAI 2012, Proceedings
167-174
页数8
DOI
出版状态已出版 - 2012
活动2nd International Workshop on Multimodal Brain Image Analysis, MBIA 2012, Held in Conjunction with the 15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012 - Nice, 法国
期限: 1 10月 20125 10月 2012

出版系列

姓名Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
7509 LNCS
ISSN(印刷版)0302-9743
ISSN(电子版)1611-3349

会议

会议2nd International Workshop on Multimodal Brain Image Analysis, MBIA 2012, Held in Conjunction with the 15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012
国家/地区法国
Nice
时期1/10/125/10/12

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