Cancer omic data based explainable AI drug recommendation inference: A traceability perspective for explainability

Jianing Xi, Dan Wang, Xuebing Yang, Wensheng Zhang, Qinghua Huang

科研成果: 期刊稿件文章同行评审

19 引用 (Scopus)

摘要

The application of Artificial Intelligence (AI) on cancer drug recommendation can prompt the development of personalized cancer therapy. However, most of the current AI drug recommendations cannot give explainable inferences, where their prediction procedures are black boxes, and are difficult to earn the trust of doctors or patients. In explainable inference, the key steps during the recommendation procedures can be located easily, facilitating model adjustment for wrong predictions and model generalization for new drugs/samples. In this paper, we analyze the necessity of developing explainable AI drug recommendation, and propose an evaluation metric called traceability rate. The traceability rate is calculated as the proportion of correct predictions that are traceable along the knowledge graph in all the ground truths. We further conduct an experiment on a benchmark drug response dataset to apply the traceability rate as evaluation metric, where the results show a trade-off between model performance and explainability. Therefore, the explainable AI drug recommendation still demands for further improvement to meet the requirement of clinical personalized therapy.

源语言英语
文章编号104144
期刊Biomedical Signal Processing and Control
79
DOI
出版状态已出版 - 1月 2023

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