Biosynthesis of antibacterial compound against multidrug resistant foodborne pathogens by Phomopsis sp. XP-8

Xixi Zhao, Yan Zhang, Junling Shi, Yanlin Liu, Yao Lu, Ziyang Lian

科研成果: 期刊稿件文章同行评审

10 引用 (Scopus)

摘要

Multi-drug resistance of foodborne pathogens has been greatly highlighted in food safety and caused a significant challenge for the development of new antibiotics and safe preservatives. The ethanol extract of Phomopsis sp. XP-8 broth showed significant inhibitory effects on multi-drug resistance of foodborne pathogens. After purification with thin-layer chromatography and liquid chromatographic analysis, the antibacterial compound was identified as methyl quercetin according to FTIR spectrum analysis and ESI-Q-TOF-MS analysis. Via substrate-feeding experiments, the mass flow for the biosynthesis of methyl quercetin was defined as (starting from glucose to phenylalanine): cinnamic acid, p-coumaric acid, quercetin, and methyl quercetin. The study revealed the capability of methyl quercetin to inhibit foodborne multi-drug resistant Escherichia coli, Staphylococcus aureus, and Salmonella shubra, as well as the capability of Phomopsis sp. XP-8 to produce methyl quercetin, showing potential application in food control.

源语言英语
页(从-至)223-231
页数9
期刊Food Control
95
DOI
出版状态已出版 - 1月 2019

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