Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus)

Zeshan Lin, Lei Chen, Xianqing Chen, Yingbin Zhong, Yue Yang, Wenhao Xia, Chang Liu, Wenbo Zhu, Han Wang, Biyao Yan, Yifeng Yang, Xing Liu, Kjersti Sternang Kvie, Knut Håkon Røed, Kun Wang, Wuhan Xiao, Haijun Wei, Guangyu Li, Rasmus Heller, M. Thomas GilbertQiang Qiu, Wen Wang, Zhipeng Li

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70 引用 (Scopus)

摘要

The reindeer is an Arctic species that exhibits distinctive biological characteristics, for which the underlying genetic basis remains largely unknown. We compared the genomes of reindeer against those of other ruminants and nonruminant mammals to reveal the genetic basis of light arrhythmicity, high vitamin D metabolic efficiency, the antler growth trait of females, and docility. We validate that two reindeer vitamin D metabolic genes (CYP27B1 and POR) show signs of positive selection and exhibit higher catalytic activity than those of other ruminants. A mutation upstream of the reindeer CCND1 gene endows an extra functional binding motif of the androgen receptor and thereby may result in female antlers. Furthermore, a mutation (proline-1172→threonine) in reindeer PER2 results in loss of binding ability with CRY1, which may explain circadian arrhythmicity in reindeer.

源语言英语
文章编号eaav6312
期刊Science
364
6446
DOI
出版状态已出版 - 2019

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