Biofilm microenvironment-responsive polymeric CO releasing micelles for enhanced amikacin efficacy

Qian Zhou, Tengjiao Wang, Kunpeng Li, Shanyu Zhang, Kun Wang, Weilin Hong, Rongjun Liu, Peng Li

科研成果: 期刊稿件文章同行评审

16 引用 (Scopus)

摘要

Biofilm-associated infections (BAI) have posed serious threats to public health. Novel therapy based on carbon monoxide (CO) is being increasingly appreciated. However, CO therapy like inhaled gas treatment was impeded owing to its low bioavailability. Besides, the direct use of CO releasing molecules (CORM) showed low therapeutic efficacy in BAI. Therefore, it is vital to improve the efficiency of CO therapy. Herein, we proposed polymeric CO releasing micelles (pCORM) from self-assembly of amphiphilic copolymers containing CORM bearing block as hydrophobic part and acryloylmorpholine block as hydrophilic part. The catechol modified CORM were conjugated through pH cleavable boronate ester bonds and releasing CO passively under biofilm microenvironment. When combined with subminimal inhibitory concentration antibiotic amikacin, pCORM could significantly enhance its bactericidal efficiency against biofilm-encapsulated multidrug-resistant bacteria, representing a promising approach to combat BAI.

源语言英语
页(从-至)561-571
页数11
期刊Journal of Controlled Release
357
DOI
出版状态已出版 - 5月 2023

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