Automated classification of touching or overlapping M-FISH chromosomes by region fusion and homolog pairing

Yongqiang Zhao, Seong G. Kong

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1 引用 (Scopus)

摘要

Automated separation and classification of touching or overlapping chromosomes in a metaphase image is a critical step in computer-aided chromosome analysis. The advent of the multiplex fluorescence in situ hybridization (M-FISH) technology enables multi-spectral chromosome image with rich spectral information and DAPI image with abundant texture information. This paper presents a fusion classification scheme to improve the segmentation of overlapping and touching chromosomes. First, the texture and spectral information is fused to partition the chromosome cluster into a series of homologous regions. Then a graph-theoretical classification and pairing method is proposed to resolve any remaining ambiguity of the aforementioned separation process. Experiment results demonstrate that the proposed method outperforms conventional multi-spectral classification methods in touching and overlapping chromosome separation.

源语言英语
页(从-至)31-39
页数9
期刊Pattern Analysis and Applications
16
1
DOI
出版状态已出版 - 2月 2013

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