Andrias Davidianus Mucus-Based Bioadhesive with Enhanced Adhesion and Wound Healing Properties

Huan Liang, Xue Ting Wang, Wan Yi Ge, Rui Zhang, Jie Liu, Liang Liang Chen, Xiao Li Xi, Wei Hong Guo, Da Chuan Yin

科研成果: 期刊稿件文章同行评审

7 引用 (Scopus)

摘要

The skin secretion of Andrias davidianus (SSAD) is a novel biological adhesive raw material under development. This material exhibits robust adhesion while maintaining the flexibility of the wound. It also has the potential for large-scale production, making it promising for practical application explore. Hence, in-depth research on methods to fine-tune SSAD properties is of great importance to promote its practical applications. Herein, we aim to enhance the adhesive and healing properties of SSAD by incorporating functional components. To achieve this goal, we selected 3,4-dihydroxy-l-phenylalanine and vaccarin as the functional components and mixed them with SSAD, resulting in a new bioadhesive, namely, a formulation termed “enhanced SSAD” (ESSAD). We found that the ESSAD exhibited superior adhesive properties, and its adhesive strength was improved compared with the SSAD. Moreover, ESSAD demonstrated a remarkable ability to promote wound healing. This study presents an SSAD-based bioadhesive formulation with enhanced properties, affirming the feasibility of developing SSAD-based adhesive materials with excellent performance and providing new evidence for the application of SSAD. This study also aims to show that SSAD can be mixed with other substances, and addition of effective components to SSAD can be studied to further adjust or improve its performance.

源语言英语
页(从-至)49931-49942
页数12
期刊ACS Applied Materials and Interfaces
15
43
DOI
出版状态已出版 - 1 11月 2023

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