A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe

Chang Liu; Jianbo Gao; Xinxin Cui; Zhipeng Li; Lei Chen; Yuan Yuan; Yaolei Zhang; Liangwei Mei; Lan Zhao; Dan Cai; Mingliang Hu; Botong Zhou; Zihe Li; Tao Qin; Huazhe Si; Guangyu Li; Zeshan Lin; Yicheng Xu; Chenglong Zhu; Yuan Yin; Chenzhou Zhang; Wenjie Xu; Qingjie Li; Kun Wang; M. Thomas; Rasmus Heller; Wen Wang; Jinghui Huang; Qiang Qiu

doi:10.1126/sciadv.abe9459

A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe

Chang Liu, Jianbo Gao, Xinxin Cui, Zhipeng Li, Lei Chen, Yuan Yuan, Yaolei Zhang, Liangwei Mei, Lan Zhao, Dan Cai, Mingliang Hu, Botong Zhou, Zihe Li, Tao Qin, Huazhe Si, Guangyu Li, Zeshan Lin, Yicheng Xu, Chenglong Zhu, Yuan YinChenzhou Zhang, Wenjie Xu, Qingjie Li, Kun Wang, M. Thomas, Rasmus Heller, Wen Wang, Jinghui Huang, Qiang Qiu

生态环境学院

科研成果: 期刊稿件 › 文章 › 同行评审

44 引用（Scopus）

摘要

The suite of adaptations associated with the extreme stature of the giraffe has long interested biologists and physiologists. By generating a high-quality chromosome-level giraffe genome and a comprehensive comparison with other ruminant genomes, we identified a robust catalog of giraffe-specific mutations. These are primarily related to cardiovascular, bone growth, vision, hearing, and circadian functions. Among them, the giraffe FGFRL1 gene is an outlier with seven unique amino acid substitutions not found in any other ruminant. Gene-edited mice with the giraffe-type FGFRL1 show exceptional hypertension resistance and higher bone mineral density, both of which are tightly connected with giraffe adaptations to high stature. Our results facilitate a deeper understanding of the molecular mechanism underpinning distinct giraffe traits, and may provide insights into the study of hypertension in humans.

源语言	英语
文章编号	eabe9459
期刊	Science Advances
卷	7
期	12
DOI	https://doi.org/10.1126/sciadv.abe9459
出版状态	已出版 - 17 3月 2021

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Liu, C., Gao, J., Cui, X., Li, Z., Chen, L., Yuan, Y., Zhang, Y., Mei, L., Zhao, L., Cai, D., Hu, M., Zhou, B., Li, Z., Qin, T., Si, H., Li, G., Lin, Z., Xu, Y., Zhu, C., ... Qiu, Q. (2021). A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe. Science Advances, 7(12), 文章 eabe9459. https://doi.org/10.1126/sciadv.abe9459

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title = "A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe",

abstract = "The suite of adaptations associated with the extreme stature of the giraffe has long interested biologists and physiologists. By generating a high-quality chromosome-level giraffe genome and a comprehensive comparison with other ruminant genomes, we identified a robust catalog of giraffe-specific mutations. These are primarily related to cardiovascular, bone growth, vision, hearing, and circadian functions. Among them, the giraffe FGFRL1 gene is an outlier with seven unique amino acid substitutions not found in any other ruminant. Gene-edited mice with the giraffe-type FGFRL1 show exceptional hypertension resistance and higher bone mineral density, both of which are tightly connected with giraffe adaptations to high stature. Our results facilitate a deeper understanding of the molecular mechanism underpinning distinct giraffe traits, and may provide insights into the study of hypertension in humans.",

author = "Chang Liu and Jianbo Gao and Xinxin Cui and Zhipeng Li and Lei Chen and Yuan Yuan and Yaolei Zhang and Liangwei Mei and Lan Zhao and Dan Cai and Mingliang Hu and Botong Zhou and Zihe Li and Tao Qin and Huazhe Si and Guangyu Li and Zeshan Lin and Yicheng Xu and Chenglong Zhu and Yuan Yin and Chenzhou Zhang and Wenjie Xu and Qingjie Li and Kun Wang and M. Thomas and Rasmus Heller and Wen Wang and Jinghui Huang and Qiang Qiu",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 The Authors, some rights reserved;",

year = "2021",

month = mar,

day = "17",

doi = "10.1126/sciadv.abe9459",

language = "英语",

volume = "7",

journal = "Science Advances",

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Liu, C, Gao, J, Cui, X, Li, Z, Chen, L, Yuan, Y, Zhang, Y, Mei, L, Zhao, L, Cai, D, Hu, M, Zhou, B, Li, Z, Qin, T, Si, H, Li, G, Lin, Z, Xu, Y, Zhu, C, Yin, Y, Zhang, C, Xu, W, Li, Q, Wang, K, Thomas, M, Heller, R, Wang, W, Huang, J & Qiu, Q 2021, 'A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe', Science Advances, 卷 7, 号码 12, eabe9459. https://doi.org/10.1126/sciadv.abe9459

TY - JOUR

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T2 - Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe

AU - Liu, Chang

AU - Gao, Jianbo

AU - Cui, Xinxin

AU - Li, Zhipeng

AU - Chen, Lei

AU - Yuan, Yuan

AU - Zhang, Yaolei

AU - Mei, Liangwei

AU - Zhao, Lan

AU - Cai, Dan

AU - Hu, Mingliang

AU - Zhou, Botong

AU - Li, Zihe

AU - Qin, Tao

AU - Si, Huazhe

AU - Li, Guangyu

AU - Lin, Zeshan

AU - Xu, Yicheng

AU - Zhu, Chenglong

AU - Yin, Yuan

AU - Zhang, Chenzhou

AU - Xu, Wenjie

AU - Li, Qingjie

AU - Wang, Kun

AU - Thomas, M.

AU - Heller, Rasmus

AU - Wang, Wen

AU - Huang, Jinghui

AU - Qiu, Qiang

PY - 2021/3/17

Y1 - 2021/3/17

N2 - The suite of adaptations associated with the extreme stature of the giraffe has long interested biologists and physiologists. By generating a high-quality chromosome-level giraffe genome and a comprehensive comparison with other ruminant genomes, we identified a robust catalog of giraffe-specific mutations. These are primarily related to cardiovascular, bone growth, vision, hearing, and circadian functions. Among them, the giraffe FGFRL1 gene is an outlier with seven unique amino acid substitutions not found in any other ruminant. Gene-edited mice with the giraffe-type FGFRL1 show exceptional hypertension resistance and higher bone mineral density, both of which are tightly connected with giraffe adaptations to high stature. Our results facilitate a deeper understanding of the molecular mechanism underpinning distinct giraffe traits, and may provide insights into the study of hypertension in humans.

AB - The suite of adaptations associated with the extreme stature of the giraffe has long interested biologists and physiologists. By generating a high-quality chromosome-level giraffe genome and a comprehensive comparison with other ruminant genomes, we identified a robust catalog of giraffe-specific mutations. These are primarily related to cardiovascular, bone growth, vision, hearing, and circadian functions. Among them, the giraffe FGFRL1 gene is an outlier with seven unique amino acid substitutions not found in any other ruminant. Gene-edited mice with the giraffe-type FGFRL1 show exceptional hypertension resistance and higher bone mineral density, both of which are tightly connected with giraffe adaptations to high stature. Our results facilitate a deeper understanding of the molecular mechanism underpinning distinct giraffe traits, and may provide insights into the study of hypertension in humans.

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SN - 2375-2548

VL - 7

JO - Science Advances

JF - Science Advances

IS - 12

M1 - eabe9459

ER -

A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe

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