A redox-responsive macrocycle based on the crown ether C7Te for enhanced bacterial inhibition

Yuchong Hao, Zhenhui Qi, Yan Ge, Tiezheng Pan, Luofeng Yu, Peng Li

科研成果: 期刊稿件文章同行评审

摘要

Due to increasing bacterial resistance to disinfectants, there is an urgent need for new therapeutic agents and strategies to effectively inhibit bacteria. Accordingly, we have designed and synthesized a novel crown ether known as C7Te, and its oxidized form C7TeO. These compounds have demonstrated antibacterial effectiveness against Gram-negative E. coli (BL21). Notably, C7Te has the capability to enhance the inhibition of E. coli and the prevention of biofilm formation by H2O2 through a redox response. It can also effectively disrupt preformed E. coli biofilms by penetrating biofilm barriers effectively. Additionally, computer modeling of the bacterial cell membrane using nanodiscs composed of phospholipids and encircled amphipathic proteins with helical belts has revealed that C7Te can insert into and interact with phospholipids and proteins. This interaction results in the disruption of the bacterial cell membrane leading to bacterial cell death. The utilization of redox-responsive crown ethers to augment the antibacterial capabilities of H2O2-based disinfectants represents a novel approach to supramolecular bacterial inhibition.

源语言英语
页(从-至)2587-2593
页数7
期刊Journal of Materials Chemistry B
12
10
DOI
出版状态已出版 - 8 2月 2024

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