A novel fluorogenic probe for visualizing the hydrogen peroxide in Parkinson's disease models

Gaobin Zhang, Zheng Li, Fangjie Chen, Duoteng Zhang, Wenhui Ji, Zhengpeng Yang, Qiong Wu, Chengwu Zhang, Lin Li, Wei Huang

科研成果: 期刊稿件文章同行评审

17 引用 (Scopus)

摘要

Parkinson's disease (PD) is closely related to the oxidative stress induced by excess hydrogen peroxide (H2O2) in organisms. Developing an efficient method for noninvasive and real-time H2O2 detection is beneficial to investigate the role played by H2O2 in PD. In this work, a novel fluorogenic probe (CBH) for living organisms H2O2 detection has been designed, synthesized and characterized. The emission of CBH in PBS solution is very weak. However, when H2O2 was added, the fluorescence of CBH solution was sharply increased for 12-fold, accompanied by the emission peak blue-shifted from 600 to 530 nm. Moreover, the response of CBH to H2O2 is highly sensitive and selective and is not affected by various ROS/RNS, anions, cations, and amino acids. Based on the good performance of CBH for H2O2 detection, it has been successfully applied to visualizing the H2O2 concentration in living cells, Zebrafish and C. elegans PD models.

源语言英语
文章编号2050013
期刊Journal of Innovative Optical Health Sciences
13
3
DOI
出版状态已出版 - 1 5月 2020

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