A multi-source fusion method to identify biomarkers for breast cancer prognosis based on dual-layer heterogeneous network

Xingyi Li, Zhelin Zhao, Ju Xiang, Jialu Hu, Xuequn Shang

科研成果: 书/报告/会议事项章节会议稿件同行评审

2 引用 (Scopus)

摘要

The prognosis of breast cancer is challenging, which is an urgent problem to be solved. The prognostic biomarkers for breast cancer can help us predict the clinical outcomes of patients, and network-based methods are widely introduced to find prognostic biomarkers. According to the difference of input biological data, existing network-based biomarker prediction methods are mainly classified into two types: integrating single-source network or multi-source networks. However, the interactome of single-source network remains incomplete, and biological networks are noisy, which will hamper the network-based identification accuracy of biomarkers. In this study, we introduce a multi-source fusion method, DualMarker, which integrates multiple biological information sources and constructs a dual-layer heterogeneous network by fast network embedding. Next, we introduce a network enhancement method to denoise the constructed dual-layer heterogeneous network, and we implement network propagation algorithm on the constructed dual-layer heterogeneous network to rank the features. After comparing with competitive methods, we find that DualMarker substantially outperforms these methods. In addition, we verify that the biomarkers identified by DualMarker are closely related to the prognosis of breast cancer patients.

源语言英语
主期刊名Proceedings - 2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022
编辑Donald Adjeroh, Qi Long, Xinghua Shi, Fei Guo, Xiaohua Hu, Srinivas Aluru, Giri Narasimhan, Jianxin Wang, Mingon Kang, Ananda M. Mondal, Jin Liu
出版商Institute of Electrical and Electronics Engineers Inc.
471-476
页数6
ISBN(电子版)9781665468190
DOI
出版状态已出版 - 2022
活动2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022 - Las Vegas, 美国
期限: 6 12月 20228 12月 2022

出版系列

姓名Proceedings - 2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022

会议

会议2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022
国家/地区美国
Las Vegas
时期6/12/228/12/22

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