摘要
A metal-free cascade reaction of 1-(8-halonaphthalen-1-yl)prop-2-yn-1-ones with sodium azide has been developed for the construction of quinolinone fused triazole frameworks. The reaction proceeded smoothly via an intramolecular metal-free version of the azide-alkyne [3 + 2] cycloaddition. A variety of quinolinone fused triazole derivatives were prepared in good to excellent yields under metal-free conditions. The practicality of this metal-free protocol was further evaluated by gram scale synthesis of quinolinone fused triazole derivatives.
源语言 | 英语 |
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文章编号 | e202200978 |
期刊 | ChemistrySelect |
卷 | 7 |
期 | 31 |
DOI | |
出版状态 | 已出版 - 19 8月 2022 |