Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy

Huaxia Shi; Wucheng Sun; Changbing Liu; Guiying Gu; Bo Ma; Weili Si; Nina Fu; Qi Zhang; Wei Huang; Xiaochen Dong

doi:10.1039/c5tb02041g

Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy

Huaxia Shi, Wucheng Sun, Changbing Liu, Guiying Gu, Bo Ma, Weili Si, Nina Fu, Qi Zhang, Wei Huang, Xiaochen Dong

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Specific targeting towards tumors and the on-site activation of photosensitizers to diagnose tumors and reduce side effects for patients are currently the main challenges for photodynamic therapy (PDT) in the clinic. Herein, uniform diiodostyryl bodipy conjugated hyaluronic acid nanoparticles (DBHA-NPs) were successfully synthesized. The evaluation of their PDT effect at both a cellular level and in animal models of tumor-bearing mice shows that the DBHA-NPs present a remarkable suppression of tumorous growth due to their specific targeting and enhanced permeability and retention (EPR) effect. More importantly, the enzyme-activated "self-assembly and disaggregation" behavior in tumors can lead to the on-site activation of DBHA-NPs, which can diagnose the tumor exactly and reduce the side effects for patients significantly. These findings confirm that DBHA-NPs have significant potential for photodynamically activated cancer theranostics in a clinical setting.

Original language	English
Pages (from-to)	113-120
Number of pages	8
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	1
DOIs	https://doi.org/10.1039/c5tb02041g
State	Published - 2016
Externally published	Yes

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10.1039/c5tb02041g

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title = "Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy",

abstract = "Specific targeting towards tumors and the on-site activation of photosensitizers to diagnose tumors and reduce side effects for patients are currently the main challenges for photodynamic therapy (PDT) in the clinic. Herein, uniform diiodostyryl bodipy conjugated hyaluronic acid nanoparticles (DBHA-NPs) were successfully synthesized. The evaluation of their PDT effect at both a cellular level and in animal models of tumor-bearing mice shows that the DBHA-NPs present a remarkable suppression of tumorous growth due to their specific targeting and enhanced permeability and retention (EPR) effect. More importantly, the enzyme-activated {"}self-assembly and disaggregation{"} behavior in tumors can lead to the on-site activation of DBHA-NPs, which can diagnose the tumor exactly and reduce the side effects for patients significantly. These findings confirm that DBHA-NPs have significant potential for photodynamically activated cancer theranostics in a clinical setting.",

author = "Huaxia Shi and Wucheng Sun and Changbing Liu and Guiying Gu and Bo Ma and Weili Si and Nina Fu and Qi Zhang and Wei Huang and Xiaochen Dong",

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year = "2016",

doi = "10.1039/c5tb02041g",

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TY - JOUR

T1 - Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy

AU - Shi, Huaxia

AU - Sun, Wucheng

AU - Liu, Changbing

AU - Gu, Guiying

AU - Ma, Bo

AU - Si, Weili

AU - Fu, Nina

AU - Zhang, Qi

AU - Huang, Wei

AU - Dong, Xiaochen

PY - 2016

Y1 - 2016

N2 - Specific targeting towards tumors and the on-site activation of photosensitizers to diagnose tumors and reduce side effects for patients are currently the main challenges for photodynamic therapy (PDT) in the clinic. Herein, uniform diiodostyryl bodipy conjugated hyaluronic acid nanoparticles (DBHA-NPs) were successfully synthesized. The evaluation of their PDT effect at both a cellular level and in animal models of tumor-bearing mice shows that the DBHA-NPs present a remarkable suppression of tumorous growth due to their specific targeting and enhanced permeability and retention (EPR) effect. More importantly, the enzyme-activated "self-assembly and disaggregation" behavior in tumors can lead to the on-site activation of DBHA-NPs, which can diagnose the tumor exactly and reduce the side effects for patients significantly. These findings confirm that DBHA-NPs have significant potential for photodynamically activated cancer theranostics in a clinical setting.

AB - Specific targeting towards tumors and the on-site activation of photosensitizers to diagnose tumors and reduce side effects for patients are currently the main challenges for photodynamic therapy (PDT) in the clinic. Herein, uniform diiodostyryl bodipy conjugated hyaluronic acid nanoparticles (DBHA-NPs) were successfully synthesized. The evaluation of their PDT effect at both a cellular level and in animal models of tumor-bearing mice shows that the DBHA-NPs present a remarkable suppression of tumorous growth due to their specific targeting and enhanced permeability and retention (EPR) effect. More importantly, the enzyme-activated "self-assembly and disaggregation" behavior in tumors can lead to the on-site activation of DBHA-NPs, which can diagnose the tumor exactly and reduce the side effects for patients significantly. These findings confirm that DBHA-NPs have significant potential for photodynamically activated cancer theranostics in a clinical setting.

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DO - 10.1039/c5tb02041g

M3 - 文章

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SN - 2050-750X

VL - 4

SP - 113

EP - 120

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 1

ER -

Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy

Abstract

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