TY - JOUR
T1 - The Synthesis and Biological Applications of Water-Soluble Perylene Diimides
AU - Wu, Jinjun
AU - Yang, Zhen
AU - Jiao, Jianmei
AU - Sun, Pengfei
AU - Fan, Quli
AU - Huang, Wei
N1 - Publisher Copyright:
© 2017, Editorial Office of Progress in Chemistry. All right reserved.
PY - 2017/2/24
Y1 - 2017/2/24
N2 - Perylene diimide and its derivatives (PDIs) have been widely used as organic field-effect transistor (OFET), organic photovoltaic cell (OPV), dye laser and organic light emitting diode (OLED) in the field of optoelectronic materials due to their photo, thermal, chemical stability and high fluorescence quantum yields. However, because of their inherent structure, PDIs have poor water-solubility and easily form aggregates, which has limited their applications in biological fields. So, it's essential to synthesize water-soluble PDIs. This paper systematically presents the synthetic methods for obtaining water-soluble PDIs by introducing anionic substituent, cationic substituent or non-ionic substituent into the imide-position or bay-region of PDIs. Some of these substituents are water-soluble, and the others will achieve the water-solubility of PDIs through electrostatic repulsion or steric hindrance. In addition, several novel biological applications have been listed, such as chemotherapy,photodynamic therapy and fluorescence imaging.PDIs can also be used as a promising photo-acoustic contrast agents due to their good light absorption and photostability.
AB - Perylene diimide and its derivatives (PDIs) have been widely used as organic field-effect transistor (OFET), organic photovoltaic cell (OPV), dye laser and organic light emitting diode (OLED) in the field of optoelectronic materials due to their photo, thermal, chemical stability and high fluorescence quantum yields. However, because of their inherent structure, PDIs have poor water-solubility and easily form aggregates, which has limited their applications in biological fields. So, it's essential to synthesize water-soluble PDIs. This paper systematically presents the synthetic methods for obtaining water-soluble PDIs by introducing anionic substituent, cationic substituent or non-ionic substituent into the imide-position or bay-region of PDIs. Some of these substituents are water-soluble, and the others will achieve the water-solubility of PDIs through electrostatic repulsion or steric hindrance. In addition, several novel biological applications have been listed, such as chemotherapy,photodynamic therapy and fluorescence imaging.PDIs can also be used as a promising photo-acoustic contrast agents due to their good light absorption and photostability.
KW - Biological application
KW - Modify
KW - PDIs
KW - Water-soluble
UR - http://www.scopus.com/inward/record.url?scp=85019357105&partnerID=8YFLogxK
U2 - 10.7536/PC160717
DO - 10.7536/PC160717
M3 - 文章
AN - SCOPUS:85019357105
SN - 1005-281X
VL - 29
SP - 216
EP - 230
JO - Progress in Chemistry
JF - Progress in Chemistry
IS - 2-3
ER -
