The origin of domestication genes in goats

Zhuqing Zheng; Xihong Wang; Ming Li; Yunjia Li; Zhirui Yang; Xiaolong Wang; Xiangyu Pan; Mian Gong; Yu Zhang; Yingwei Guo; Yu Wang; Jing Liu; Yudong Cai; Qiuming Chen; Moses Okpeku; Moses Okpeku; Moses Okpeku; Licia Colli; Dawei Cai; Kun Wang; Shisheng Huang; Tad S. Sonstegard; Ali Esmailizadeh; Wenguang Zhang; T. Tingting; Yangbin Xu; Naiyi Xu; Yi Yang; Jianlin Han; Jianlin Han; Lei Chen; Joséphine Lesur; Kevin G. Daly; Daniel G. Bradley; Rasmus Heller; Guojie Zhang; Wen Wang; Wen Wang; Wen Wang; Yulin Chen; Yu Jiang

doi:10.1126/sciadv.aaz5216

The origin of domestication genes in goats

Zhuqing Zheng, Xihong Wang, Ming Li, Yunjia Li, Zhirui Yang, Xiaolong Wang, Xiangyu Pan, Mian Gong, Yu Zhang, Yingwei Guo, Yu Wang, Jing Liu, Yudong Cai, Qiuming Chen, Moses Okpeku, Moses Okpeku, Moses Okpeku, Licia Colli, Dawei Cai, Kun WangShisheng Huang, Tad S. Sonstegard, Ali Esmailizadeh, Wenguang Zhang, T. Tingting, Yangbin Xu, Naiyi Xu, Yi Yang, Jianlin Han, Jianlin Han, Lei Chen, Joséphine Lesur, Kevin G. Daly, Daniel G. Bradley, Rasmus Heller, Guojie Zhang, Wen Wang, Wen Wang, Wen Wang, Yulin Chen, Yu Jiang

School of Ecology and Environment

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically.

Original language	English
Article number	EAAZ5216
Journal	Science Advances
Volume	6
Issue number	21
DOIs	https://doi.org/10.1126/sciadv.aaz5216
State	Published - 1 May 2020

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@article{57f019c8c24e475ab0255ee5aef8b309,

title = "The origin of domestication genes in goats",

abstract = "Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically.",

author = "Zhuqing Zheng and Xihong Wang and Ming Li and Yunjia Li and Zhirui Yang and Xiaolong Wang and Xiangyu Pan and Mian Gong and Yu Zhang and Yingwei Guo and Yu Wang and Jing Liu and Yudong Cai and Qiuming Chen and Moses Okpeku and Moses Okpeku and Moses Okpeku and Licia Colli and Dawei Cai and Kun Wang and Shisheng Huang and Sonstegard, {Tad S.} and Ali Esmailizadeh and Wenguang Zhang and T. Tingting and Yangbin Xu and Naiyi Xu and Yi Yang and Jianlin Han and Jianlin Han and Lei Chen and Jos{\'e}phine Lesur and Daly, {Kevin G.} and Bradley, {Daniel G.} and Rasmus Heller and Guojie Zhang and Wen Wang and Wen Wang and Wen Wang and Yulin Chen and Yu Jiang",

year = "2020",

month = may,

day = "1",

doi = "10.1126/sciadv.aaz5216",

language = "英语",

volume = "6",

journal = "Science Advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

number = "21",

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Zheng, Z, Wang, X, Li, M, Li, Y, Yang, Z, Wang, X, Pan, X, Gong, M, Zhang, Y, Guo, Y, Wang, Y, Liu, J, Cai, Y, Chen, Q, Okpeku, M, Okpeku, M, Okpeku, M, Colli, L, Cai, D, Wang, K, Huang, S, Sonstegard, TS, Esmailizadeh, A, Zhang, W, Tingting, T, Xu, Y, Xu, N, Yang, Y, Han, J, Han, J, Chen, L, Lesur, J, Daly, KG, Bradley, DG, Heller, R, Zhang, G, Wang, W , Wang, W , Wang, W, Chen, Y & Jiang, Y 2020, 'The origin of domestication genes in goats', Science Advances, vol. 6, no. 21, EAAZ5216. https://doi.org/10.1126/sciadv.aaz5216

TY - JOUR

T1 - The origin of domestication genes in goats

AU - Zheng, Zhuqing

AU - Wang, Xihong

AU - Li, Ming

AU - Li, Yunjia

AU - Yang, Zhirui

AU - Wang, Xiaolong

AU - Pan, Xiangyu

AU - Gong, Mian

AU - Zhang, Yu

AU - Guo, Yingwei

AU - Wang, Yu

AU - Liu, Jing

AU - Cai, Yudong

AU - Chen, Qiuming

AU - Okpeku, Moses

AU - Colli, Licia

AU - Cai, Dawei

AU - Wang, Kun

AU - Huang, Shisheng

AU - Sonstegard, Tad S.

AU - Esmailizadeh, Ali

AU - Zhang, Wenguang

AU - Tingting, T.

AU - Xu, Yangbin

AU - Xu, Naiyi

AU - Yang, Yi

AU - Han, Jianlin

AU - Chen, Lei

AU - Lesur, Joséphine

AU - Daly, Kevin G.

AU - Bradley, Daniel G.

AU - Heller, Rasmus

AU - Zhang, Guojie

AU - Wang, Wen

AU - Chen, Yulin

AU - Jiang, Yu

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically.

AB - Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically.

UR - http://www.scopus.com/inward/record.url?scp=85086169260&partnerID=8YFLogxK

U2 - 10.1126/sciadv.aaz5216

DO - 10.1126/sciadv.aaz5216

M3 - 文章

C2 - 32671210

AN - SCOPUS:85086169260

SN - 2375-2548

VL - 6

JO - Science Advances

JF - Science Advances

IS - 21

M1 - EAAZ5216

ER -

The origin of domestication genes in goats

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