Abstract
Block copolymers not only combine properties of different segments but also generate new application prospects. Poly(α-amino acid)-b-poly(tetrahydrofuran)-b-poly(α-amino acid) (PAA-PTHF-PAA) is one of the copolymers. In this contribution, di-hydroxyl-ended HO-PTHF-OH is transferred into di-oxyamino-ended H2NO-PTHF-ONH2 quantitatively, which is used as a macroinitiator to polymerize sarcosine N-thiocarboxyanhydride (Sar-NTA) and N-phenyoxycarbonyl N-ε-carbobenzyloxy-D-lysine (ZDL-NPC). Well-defined triblock PAA-NHO-PTHF-ONH-PAA is produced with high molecular weight (up to 25.3 kg/mol) and narrow dispersity. The amphiphilic PSar-NHO-PTHF-ONH-PSar (STS) self-assembles into micelles with uniform diameters of 30—40 nm according to DLS. Owing to oxygen amide groups inside the backbone of these copolymers, the polyether-poly(amino acid)s block copolymers are cleavable under an acidic environment and therefore have potential applications in smart biomedicine and engineering.
Original language | English |
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Pages (from-to) | 2852-2856 |
Number of pages | 5 |
Journal | Chinese Journal of Chemistry |
Volume | 39 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2021 |
Keywords
- Amino acid
- Block copolymers
- End group transformation
- Peptides
- Peptoids