TY - JOUR
T1 - Synthesis of modified H4-BINOL ligands and their applications in the asymmetric addition of diethylzinc to aromatic aldehydes
AU - Lu, Yong Na
AU - Guo, Qun Sheng
AU - Jiang, Fu Yong
AU - Li, Jin Shan
PY - 2006/7/31
Y1 - 2006/7/31
N2 - Two new ligands (S,S)-3-(1,1′-bi-2-naphthol-3-yl)-5,6,7,8-tetrahydro-1,1′-bi-2-naphthol [(S,S)-1] and (S)-3-(morpholin-4-ylmethyl)-H4-BINOL [(S)-2] have been synthesized via Suzuki cross-coupling reaction and a Mannich-type reaction, respectively. In the presence of titanium tetraisopropoxide, 0.8 mol % of ligand (S,S)-1 catalyzed the asymmetric addition of diethylzinc to aromatic aldehydes in good yield and with high enantioselectivity.
AB - Two new ligands (S,S)-3-(1,1′-bi-2-naphthol-3-yl)-5,6,7,8-tetrahydro-1,1′-bi-2-naphthol [(S,S)-1] and (S)-3-(morpholin-4-ylmethyl)-H4-BINOL [(S)-2] have been synthesized via Suzuki cross-coupling reaction and a Mannich-type reaction, respectively. In the presence of titanium tetraisopropoxide, 0.8 mol % of ligand (S,S)-1 catalyzed the asymmetric addition of diethylzinc to aromatic aldehydes in good yield and with high enantioselectivity.
UR - http://www.scopus.com/inward/record.url?scp=33746396402&partnerID=8YFLogxK
U2 - 10.1016/j.tetasy.2006.06.042
DO - 10.1016/j.tetasy.2006.06.042
M3 - 文章
AN - SCOPUS:33746396402
SN - 0957-4166
VL - 17
SP - 1842
EP - 1845
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 12
ER -