Synthesis, crystal structures and in vitro antitumor activities of some organoantimony arylhydroxamates

Guo Cang Wang; Yong Na Lu; Jian Xiao; Lin Yu; Hai Bin Song; Jin Shan Li; Jing Rong Cui; Rui Qing Wang; Fu Xiang Ran

doi:10.1016/j.jorganchem.2004.09.002

Synthesis, crystal structures and in vitro antitumor activities of some organoantimony arylhydroxamates

Guo Cang Wang, Yong Na Lu, Jian Xiao, Lin Yu, Hai Bin Song, Jin Shan Li, Jing Rong Cui, Rui Qing Wang, Fu Xiang Ran

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

A series of novel organoantimony arylhydroxamates with the formulae [Ar ₃SbL ₂] ^-[HNEt ₃] ⁺ (LH = arylhydroxamic acid; Ar = C ₆H ₅, 4-CH ₃C ₆H ₄, 3-CH ₃C ₆H ₄, 4-ClC ₆H ₄, 4-FC ₆H ₄) and (4-CH ₃C ₆H ₄) ₄SbL were synthesized and characterized by elemental analysis, IR, ¹H NMR and mass spectroscopy. The crystal structures of (4-CH ₃C ₆H ₄) ₄SbL and [Ph ₃SbL ₂] ^-[HNEt ₃] ⁺ were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against three human cancer cells are reported.

Original language	English
Pages (from-to)	151-156
Number of pages	6
Journal	Journal of Organometallic Chemistry
Volume	690
Issue number	1
DOIs	https://doi.org/10.1016/j.jorganchem.2004.09.002
State	Published - 3 Jan 2005
Externally published	Yes

Keywords

Antitumor activity
Arylhydroxamic acid
Crystal structures
Organoantimony

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jorganchem.2004.09.002

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title = "Synthesis, crystal structures and in vitro antitumor activities of some organoantimony arylhydroxamates",

abstract = "A series of novel organoantimony arylhydroxamates with the formulae [Ar 3SbL 2] -[HNEt 3] + (LH = arylhydroxamic acid; Ar = C 6H 5, 4-CH 3C 6H 4, 3-CH 3C 6H 4, 4-ClC 6H 4, 4-FC 6H 4) and (4-CH 3C 6H 4) 4SbL were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (4-CH 3C 6H 4) 4SbL and [Ph 3SbL 2] -[HNEt 3] + were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against three human cancer cells are reported.",

keywords = "Antitumor activity, Arylhydroxamic acid, Crystal structures, Organoantimony",

author = "Wang, {Guo Cang} and Lu, {Yong Na} and Jian Xiao and Lin Yu and Song, {Hai Bin} and Li, {Jin Shan} and Cui, {Jing Rong} and Wang, {Rui Qing} and Ran, {Fu Xiang}",

year = "2005",

month = jan,

day = "3",

doi = "10.1016/j.jorganchem.2004.09.002",

language = "英语",

volume = "690",

pages = "151--156",

journal = "Journal of Organometallic Chemistry",

issn = "0022-328X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Synthesis, crystal structures and in vitro antitumor activities of some organoantimony arylhydroxamates

AU - Wang, Guo Cang

AU - Lu, Yong Na

AU - Xiao, Jian

AU - Yu, Lin

AU - Song, Hai Bin

AU - Li, Jin Shan

AU - Cui, Jing Rong

AU - Wang, Rui Qing

AU - Ran, Fu Xiang

PY - 2005/1/3

Y1 - 2005/1/3

N2 - A series of novel organoantimony arylhydroxamates with the formulae [Ar 3SbL 2] -[HNEt 3] + (LH = arylhydroxamic acid; Ar = C 6H 5, 4-CH 3C 6H 4, 3-CH 3C 6H 4, 4-ClC 6H 4, 4-FC 6H 4) and (4-CH 3C 6H 4) 4SbL were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (4-CH 3C 6H 4) 4SbL and [Ph 3SbL 2] -[HNEt 3] + were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against three human cancer cells are reported.

AB - A series of novel organoantimony arylhydroxamates with the formulae [Ar 3SbL 2] -[HNEt 3] + (LH = arylhydroxamic acid; Ar = C 6H 5, 4-CH 3C 6H 4, 3-CH 3C 6H 4, 4-ClC 6H 4, 4-FC 6H 4) and (4-CH 3C 6H 4) 4SbL were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (4-CH 3C 6H 4) 4SbL and [Ph 3SbL 2] -[HNEt 3] + were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against three human cancer cells are reported.

KW - Antitumor activity

KW - Arylhydroxamic acid

KW - Crystal structures

KW - Organoantimony

UR - http://www.scopus.com/inward/record.url?scp=11144323888&partnerID=8YFLogxK

U2 - 10.1016/j.jorganchem.2004.09.002

DO - 10.1016/j.jorganchem.2004.09.002

M3 - 文章

AN - SCOPUS:11144323888

SN - 0022-328X

VL - 690

SP - 151

EP - 156

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 1

ER -

Synthesis, crystal structures and in vitro antitumor activities of some organoantimony arylhydroxamates

Abstract

Keywords

UN SDGs

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