Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

Guo Cang Wang; Jian Xiao; Lin Yu; Jin Shan Li; Jing Rong Cui; Rui Qing Wang; Fu Xiang Ran

doi:10.1016/j.jorganchem.2004.02.015

Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

Guo Cang Wang, Jian Xiao, Lin Yu, Jin Shan Li, Jing Rong Cui, Rui Qing Wang, Fu Xiang Ran

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A series of novel arylantimony derivatives of analogues of demethylcantharimide with the formulae Ar_nSbL_(5-n) and Ar_nSbL^′_(5-n) (LH=N-hydroxy-demethyldehydrogencantharimide, L^′ H=N-hydroxy-demethylcantharimide, n=3, 4; Ar=C₆H₅, 4-CH₃C₆H₄, 3-CH₃C₆H₄, 2-CH₃C₆ H₄, 4-ClC₆H₄, 4-FC₆H₄) were synthesized and characterized by elemental analysis, IR, ¹H NMR and mass spectroscopy. The crystal structures of (C₆H₅)₄SbL, (4-CH₃C₆H₄)₃SbL₂ and (3-CH₃C₆H₄)₃ SbL^′₂ were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported.

Original language	English
Pages (from-to)	1631-1638
Number of pages	8
Journal	Journal of Organometallic Chemistry
Volume	689
Issue number	9
DOIs	https://doi.org/10.1016/j.jorganchem.2004.02.015
State	Published - 1 May 2004
Externally published	Yes

Keywords

Antimony
Antitumor activity
Crystal structures
Demethylcantharimide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jorganchem.2004.02.015

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@article{46f560bf2ada4501bae2ff412719d2fb,

title = "Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide",

abstract = "A series of novel arylantimony derivatives of analogues of demethylcantharimide with the formulae ArnSbL(5-n) and ArnSbL′(5-n) (LH=N-hydroxy-demethyldehydrogencantharimide, L′ H=N-hydroxy-demethylcantharimide, n=3, 4; Ar=C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6 H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (C6H5)4SbL, (4-CH3C6H4)3SbL2 and (3-CH3C6H4)3 SbL′2 were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported.",

keywords = "Antimony, Antitumor activity, Crystal structures, Demethylcantharimide",

author = "Wang, {Guo Cang} and Jian Xiao and Lin Yu and Li, {Jin Shan} and Cui, {Jing Rong} and Wang, {Rui Qing} and Ran, {Fu Xiang}",

year = "2004",

month = may,

day = "1",

doi = "10.1016/j.jorganchem.2004.02.015",

language = "英语",

volume = "689",

pages = "1631--1638",

journal = "Journal of Organometallic Chemistry",

issn = "0022-328X",

publisher = "Elsevier B.V.",

number = "9",

}

TY - JOUR

T1 - Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

AU - Wang, Guo Cang

AU - Xiao, Jian

AU - Yu, Lin

AU - Li, Jin Shan

AU - Cui, Jing Rong

AU - Wang, Rui Qing

AU - Ran, Fu Xiang

PY - 2004/5/1

Y1 - 2004/5/1

N2 - A series of novel arylantimony derivatives of analogues of demethylcantharimide with the formulae ArnSbL(5-n) and ArnSbL′(5-n) (LH=N-hydroxy-demethyldehydrogencantharimide, L′ H=N-hydroxy-demethylcantharimide, n=3, 4; Ar=C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6 H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (C6H5)4SbL, (4-CH3C6H4)3SbL2 and (3-CH3C6H4)3 SbL′2 were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported.

AB - A series of novel arylantimony derivatives of analogues of demethylcantharimide with the formulae ArnSbL(5-n) and ArnSbL′(5-n) (LH=N-hydroxy-demethyldehydrogencantharimide, L′ H=N-hydroxy-demethylcantharimide, n=3, 4; Ar=C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6 H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (C6H5)4SbL, (4-CH3C6H4)3SbL2 and (3-CH3C6H4)3 SbL′2 were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported.

KW - Antimony

KW - Antitumor activity

KW - Crystal structures

KW - Demethylcantharimide

UR - http://www.scopus.com/inward/record.url?scp=1842716619&partnerID=8YFLogxK

U2 - 10.1016/j.jorganchem.2004.02.015

DO - 10.1016/j.jorganchem.2004.02.015

M3 - 文章

AN - SCOPUS:1842716619

SN - 0022-328X

VL - 689

SP - 1631

EP - 1638

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 9

ER -

Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

Abstract

Keywords

UN SDGs

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