Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C5H 5FeC5H4CO2SbPh4 and (C5H5FeC5H4CO2) 2Sb(4-CH3C6H4)3

Run Chang Liu; Yong Qiang Ma; Lin Yu; Jin Shan Li; Jing Rong Cui; Rui Qing Wang

doi:10.1002/aoc.491

Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C₅H ₅FeC₅H₄CO₂SbPh₄ and (C₅H₅FeC₅H₄CO₂) ₂Sb(4-CH₃C₆H₄)₃

Run Chang Liu, Yong Qiang Ma, Lin Yu, Jin Shan Li, Jing Rong Cui, Rui Qing Wang

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A series of arylantimony ferrocenecarboxylates with the formula (C ₅H₅FeC₅H₄CO₂) _nSbAr_(5-n) (n = 1, 2; Ar = C₆H₅, 4-CH₃C₆H₄, 3-CH₃C₆H ₄, 2-CH₃C₆H₄, 4-ClC ₆H₄, 4-FC₆H₄) were synthesized and characterized by elemental analysis, IR, ¹H NMR and mass spectra. The crystal structures of (C₅H₅FeC₅H ₄CO₂)₂Sb(4-CH₃C₆H ₄)₃ and C₅H₅FeC₅H ₄CO₂SbPh₄ were determined by X-ray diffraction. Four human neoplastic cell lines (HL-60, Bel-7402, KB and Hela) were used to screen these compounds. The results indicate that these compounds at 10 μM show certain in vitro antitumor activities.

Original language	English
Pages (from-to)	662-668
Number of pages	7
Journal	Applied Organometallic Chemistry
Volume	17
Issue number	9
DOIs	https://doi.org/10.1002/aoc.491
State	Published - 1 Sep 2003
Externally published	Yes

Keywords

Antitumor activity
Arylantimony
Crystal structure
Ferrocenecarboxylate

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10.1002/aoc.491

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@article{7bcd674ef96c4f4ebd4a0646619a14fa,

title = "Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C5H 5FeC5H4CO2SbPh4 and (C5H5FeC5H4CO2) 2Sb(4-CH3C6H4)3",

abstract = "A series of arylantimony ferrocenecarboxylates with the formula (C 5H5FeC5H4CO2) nSbAr(5-n) (n = 1, 2; Ar = C6H5, 4-CH3C6H4, 3-CH3C6H 4, 2-CH3C6H4, 4-ClC 6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structures of (C5H5FeC5H 4CO2)2Sb(4-CH3C6H 4)3 and C5H5FeC5H 4CO2SbPh4 were determined by X-ray diffraction. Four human neoplastic cell lines (HL-60, Bel-7402, KB and Hela) were used to screen these compounds. The results indicate that these compounds at 10 μM show certain in vitro antitumor activities.",

keywords = "Antitumor activity, Arylantimony, Crystal structure, Ferrocenecarboxylate",

author = "Liu, {Run Chang} and Ma, {Yong Qiang} and Lin Yu and Li, {Jin Shan} and Cui, {Jing Rong} and Wang, {Rui Qing}",

year = "2003",

month = sep,

day = "1",

doi = "10.1002/aoc.491",

language = "英语",

volume = "17",

pages = "662--668",

journal = "Applied Organometallic Chemistry",

issn = "0268-2605",

publisher = "John Wiley and Sons Ltd",

number = "9",

}

Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C₅H ₅FeC₅H₄CO₂SbPh₄ and (C₅H₅FeC₅H₄CO₂) ₂Sb(4-CH₃C₆H₄)₃. / Liu, Run Chang; Ma, Yong Qiang; Yu, Lin et al.
In: Applied Organometallic Chemistry, Vol. 17, No. 9, 01.09.2003, p. 662-668.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C5H 5FeC5H4CO2SbPh4 and (C5H5FeC5H4CO2) 2Sb(4-CH3C6H4)3

AU - Liu, Run Chang

AU - Ma, Yong Qiang

AU - Yu, Lin

AU - Li, Jin Shan

AU - Cui, Jing Rong

AU - Wang, Rui Qing

PY - 2003/9/1

Y1 - 2003/9/1

N2 - A series of arylantimony ferrocenecarboxylates with the formula (C 5H5FeC5H4CO2) nSbAr(5-n) (n = 1, 2; Ar = C6H5, 4-CH3C6H4, 3-CH3C6H 4, 2-CH3C6H4, 4-ClC 6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structures of (C5H5FeC5H 4CO2)2Sb(4-CH3C6H 4)3 and C5H5FeC5H 4CO2SbPh4 were determined by X-ray diffraction. Four human neoplastic cell lines (HL-60, Bel-7402, KB and Hela) were used to screen these compounds. The results indicate that these compounds at 10 μM show certain in vitro antitumor activities.

AB - A series of arylantimony ferrocenecarboxylates with the formula (C 5H5FeC5H4CO2) nSbAr(5-n) (n = 1, 2; Ar = C6H5, 4-CH3C6H4, 3-CH3C6H 4, 2-CH3C6H4, 4-ClC 6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structures of (C5H5FeC5H 4CO2)2Sb(4-CH3C6H 4)3 and C5H5FeC5H 4CO2SbPh4 were determined by X-ray diffraction. Four human neoplastic cell lines (HL-60, Bel-7402, KB and Hela) were used to screen these compounds. The results indicate that these compounds at 10 μM show certain in vitro antitumor activities.

KW - Antitumor activity

KW - Arylantimony

KW - Crystal structure

KW - Ferrocenecarboxylate

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U2 - 10.1002/aoc.491

DO - 10.1002/aoc.491

M3 - 文章

AN - SCOPUS:0041358818

SN - 0268-2605

VL - 17

SP - 662

EP - 668

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 9

ER -

Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C₅H ₅FeC₅H₄CO₂SbPh₄ and (C₅H₅FeC₅H₄CO₂) ₂Sb(4-CH₃C₆H₄)₃

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