Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures

Lin Yu; Yong Qiang Ma; Guo Cang Wang; Jin Shan Li; Guan Hua Du; Juan Juan Hu

doi:10.1016/S0022-328X(03)00547-3

Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures

Lin Yu, Yong Qiang Ma, Guo Cang Wang, Jin Shan Li, Guan Hua Du, Juan Juan Hu

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar₃Bi(O₂CCHR¹ CHR²GePh₃)₂ (R¹=H, CH₃; R²=H, Ph; Ar=Ph, 4-CH₃C₆H₄, 4-FC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄) were synthesized and characterized by elemental analysis, IR, ¹H-NMR and mass spectroscopy. The crystal structures of (4-BrC₆H₄) ₃Bi(O₂CCH₂CH₂ GePh₃)₂ and (4-BrC₆H₄) ₃Bi[O₂CCH(CH₃)CH₂ GePh₃]₂ were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.

Original language	English
Pages (from-to)	173-180
Number of pages	8
Journal	Journal of Organometallic Chemistry
Volume	679
Issue number	2
DOIs	https://doi.org/10.1016/S0022-328X(03)00547-3
State	Published - 15 Aug 2003
Externally published	Yes

Keywords

Antitumor activity
Bismuth
Crystal structures
Germanium

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10.1016/S0022-328X(03)00547-3

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@article{bf9e62123f5f47dfb94ac973204e9d90,

title = "Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures",

abstract = "A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar3Bi(O2CCHR1 CHR2GePh3)2 (R1=H, CH3; R2=H, Ph; Ar=Ph, 4-CH3C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H-NMR and mass spectroscopy. The crystal structures of (4-BrC6H4) 3Bi(O2CCH2CH2 GePh3)2 and (4-BrC6H4) 3Bi[O2CCH(CH3)CH2 GePh3]2 were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.",

keywords = "Antitumor activity, Bismuth, Crystal structures, Germanium",

author = "Lin Yu and Ma, {Yong Qiang} and Wang, {Guo Cang} and Li, {Jin Shan} and Du, {Guan Hua} and Hu, {Juan Juan}",

year = "2003",

month = aug,

day = "15",

doi = "10.1016/S0022-328X(03)00547-3",

language = "英语",

volume = "679",

pages = "173--180",

journal = "Journal of Organometallic Chemistry",

issn = "0022-328X",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures

AU - Yu, Lin

AU - Ma, Yong Qiang

AU - Wang, Guo Cang

AU - Li, Jin Shan

AU - Du, Guan Hua

AU - Hu, Juan Juan

PY - 2003/8/15

Y1 - 2003/8/15

N2 - A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar3Bi(O2CCHR1 CHR2GePh3)2 (R1=H, CH3; R2=H, Ph; Ar=Ph, 4-CH3C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H-NMR and mass spectroscopy. The crystal structures of (4-BrC6H4) 3Bi(O2CCH2CH2 GePh3)2 and (4-BrC6H4) 3Bi[O2CCH(CH3)CH2 GePh3]2 were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.

AB - A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar3Bi(O2CCHR1 CHR2GePh3)2 (R1=H, CH3; R2=H, Ph; Ar=Ph, 4-CH3C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H-NMR and mass spectroscopy. The crystal structures of (4-BrC6H4) 3Bi(O2CCH2CH2 GePh3)2 and (4-BrC6H4) 3Bi[O2CCH(CH3)CH2 GePh3]2 were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.

KW - Antitumor activity

KW - Bismuth

KW - Crystal structures

KW - Germanium

UR - http://www.scopus.com/inward/record.url?scp=0042074667&partnerID=8YFLogxK

U2 - 10.1016/S0022-328X(03)00547-3

DO - 10.1016/S0022-328X(03)00547-3

M3 - 文章

AN - SCOPUS:0042074667

SN - 0022-328X

VL - 679

SP - 173

EP - 180

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 2

ER -

Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures

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Keywords

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