Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenylcarboxylate derivatives and the crystal structures of [C5H5FeC5H4C(CH3)=CHCOO] (see abstract)

Lin Yu; Yong Qiang Ma; Run Chang Liu; Guo Cang Wang; Jin Shan Li; Guan Hua Du; Juan Juan Hu

doi:10.1016/j.poly.2003.12.002

Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenylcarboxylate derivatives and the crystal structures of [C₅H₅FeC₅H₄C(CH₃)=CHCOO] (see abstract)

Lin Yu, Yong Qiang Ma, Run Chang Liu, Guo Cang Wang, Jin Shan Li, Guan Hua Du, Juan Juan Hu

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A series of novel arylantimony ferrocenylcarboxylate derivatives with the formulae [C₅H₅FeC₅H₄C(CH ₃)=CHCOO]₂SbAr₃ and [4-(C₅H ₅FeC₅H₄)C₆H₄COO] ₂SbAr₃ (Ar = C₆H₅, 4-CH ₃C₆H₄, 4-ClC₆H₄, 4-FC₆H₄) were synthesized and characterized by elemental analysis, IR and ¹H NMR. The crystal structures of [C ₅H₅FeC₅H₄C(CH₃)=CHCOO] ₂Sb(C₆H₄F-4)₃ and [4-(C ₅H₅FeC₅H₄)C₆H ₄COO]₂Sb(C₆H₄F-4)₃ were determined by X-ray diffraction. The two sets of crystal X-ray data show that the antimony atom of the former has a special six-coordinate geometry while that of the latter has a general five-coordinate geometry. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that [C₅H₅FeC ₅H₄C(CH₃)=CHCO₂]₂Sb(C₆H₄Cl-4)₃ and [C₅H ₅FeC₅H₄C(CH₃)=CHCO₂] ₂Sb(C₆H₄F-4)₃ at 5 μM show relatively good in vitro antitumor activities.

Original language	English
Pages (from-to)	823-829
Number of pages	7
Journal	Polyhedron
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.poly.2003.12.002
State	Published - 4 Mar 2004
Externally published	Yes

Keywords

Antimony
Antitumor activity
Crystal structures
Ferrocenylcarboxylate

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10.1016/j.poly.2003.12.002

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@article{781db2b150ec4769b427954bcf0e0e74,

title = "Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenylcarboxylate derivatives and the crystal structures of [C5H5FeC5H4C(CH3)=CHCOO] (see abstract)",

abstract = "A series of novel arylantimony ferrocenylcarboxylate derivatives with the formulae [C5H5FeC5H4C(CH 3)=CHCOO]2SbAr3 and [4-(C5H 5FeC5H4)C6H4COO] 2SbAr3 (Ar = C6H5, 4-CH 3C6H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR and 1H NMR. The crystal structures of [C 5H5FeC5H4C(CH3)=CHCOO] 2Sb(C6H4F-4)3 and [4-(C 5H5FeC5H4)C6H 4COO]2Sb(C6H4F-4)3 were determined by X-ray diffraction. The two sets of crystal X-ray data show that the antimony atom of the former has a special six-coordinate geometry while that of the latter has a general five-coordinate geometry. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that [C5H5FeC 5H4C(CH3)=CHCO2]2 Sb(C6H4Cl-4)3 and [C5H 5FeC5H4C(CH3)=CHCO2] 2Sb(C6H4F-4)3 at 5 μM show relatively good in vitro antitumor activities.",

keywords = "Antimony, Antitumor activity, Crystal structures, Ferrocenylcarboxylate",

author = "Lin Yu and Ma, {Yong Qiang} and Liu, {Run Chang} and Wang, {Guo Cang} and Li, {Jin Shan} and Du, {Guan Hua} and Hu, {Juan Juan}",

year = "2004",

month = mar,

day = "4",

doi = "10.1016/j.poly.2003.12.002",

language = "英语",

volume = "23",

pages = "823--829",

journal = "Polyhedron",

issn = "0277-5387",

publisher = "Elsevier Ltd",

number = "5",

}

TY - JOUR

T1 - Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenylcarboxylate derivatives and the crystal structures of [C5H5FeC5H4C(CH3)=CHCOO] (see abstract)

AU - Yu, Lin

AU - Ma, Yong Qiang

AU - Liu, Run Chang

AU - Wang, Guo Cang

AU - Li, Jin Shan

AU - Du, Guan Hua

AU - Hu, Juan Juan

PY - 2004/3/4

Y1 - 2004/3/4

N2 - A series of novel arylantimony ferrocenylcarboxylate derivatives with the formulae [C5H5FeC5H4C(CH 3)=CHCOO]2SbAr3 and [4-(C5H 5FeC5H4)C6H4COO] 2SbAr3 (Ar = C6H5, 4-CH 3C6H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR and 1H NMR. The crystal structures of [C 5H5FeC5H4C(CH3)=CHCOO] 2Sb(C6H4F-4)3 and [4-(C 5H5FeC5H4)C6H 4COO]2Sb(C6H4F-4)3 were determined by X-ray diffraction. The two sets of crystal X-ray data show that the antimony atom of the former has a special six-coordinate geometry while that of the latter has a general five-coordinate geometry. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that [C5H5FeC 5H4C(CH3)=CHCO2]2 Sb(C6H4Cl-4)3 and [C5H 5FeC5H4C(CH3)=CHCO2] 2Sb(C6H4F-4)3 at 5 μM show relatively good in vitro antitumor activities.

AB - A series of novel arylantimony ferrocenylcarboxylate derivatives with the formulae [C5H5FeC5H4C(CH 3)=CHCOO]2SbAr3 and [4-(C5H 5FeC5H4)C6H4COO] 2SbAr3 (Ar = C6H5, 4-CH 3C6H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR and 1H NMR. The crystal structures of [C 5H5FeC5H4C(CH3)=CHCOO] 2Sb(C6H4F-4)3 and [4-(C 5H5FeC5H4)C6H 4COO]2Sb(C6H4F-4)3 were determined by X-ray diffraction. The two sets of crystal X-ray data show that the antimony atom of the former has a special six-coordinate geometry while that of the latter has a general five-coordinate geometry. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that [C5H5FeC 5H4C(CH3)=CHCO2]2 Sb(C6H4Cl-4)3 and [C5H 5FeC5H4C(CH3)=CHCO2] 2Sb(C6H4F-4)3 at 5 μM show relatively good in vitro antitumor activities.

KW - Antimony

KW - Antitumor activity

KW - Crystal structures

KW - Ferrocenylcarboxylate

UR - http://www.scopus.com/inward/record.url?scp=1242343799&partnerID=8YFLogxK

U2 - 10.1016/j.poly.2003.12.002

DO - 10.1016/j.poly.2003.12.002

M3 - 文章

AN - SCOPUS:1242343799

SN - 0277-5387

VL - 23

SP - 823

EP - 829

JO - Polyhedron

JF - Polyhedron

IS - 5

ER -

Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenylcarboxylate derivatives and the crystal structures of [C₅H₅FeC₅H₄C(CH₃)=CHCOO] (see abstract)

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