TY - GEN
T1 - Super-resolved Estimation of White Matter Microstructure via 3D Conditional Latent Diffusion Model
AU - Ma, Jiquan
AU - Gao, Yihang
AU - Jiang, Haotian
AU - Gu, Jing
AU - Khairullina, Diliara
AU - Cui, Hui
AU - Chen, Geng
N1 - Publisher Copyright:
© 2024 IEEE.
PY - 2024
Y1 - 2024
N2 - As a powerful microstructural imaging technique, neurite orientation dispersion and density imaging (NODDI) provides detailed insights into brain microstructures. Its clinical application is often restricted by the necessity for high-quality scanning, which can be challenging to achieve in practical settings. To overcome this limitation, we propose an innovative 3D conditional latent diffusion model (3D-CLDM) to generate high-quality NODDI index maps from low-resolution diffusion magnetic resonance imaging data. The 3D-CLDM is a two-stage super-resolved microstructure estimation model that includes training a vector quantized generative adversarial network and a diffusion model. It leverages the sophisticated high-dimensional data modeling capabilities of the conditional latent diffusion model to effectively capture and represent intricate microstructural features that are difficult to detect with conventional techniques. We conducted comprehensive experiments using data from the human connectome project to rigorously assess our model's performance. The results reveal that our approach not only significantly improves the quality of super-resolved microstructural estimation but also surpasses current state-of-the-art models in both qualitative and quantitative evaluations. This highlights the potential of 3D-CLDM to advance brain microstructure imaging, making it more feasible and effective for clinical applications.
AB - As a powerful microstructural imaging technique, neurite orientation dispersion and density imaging (NODDI) provides detailed insights into brain microstructures. Its clinical application is often restricted by the necessity for high-quality scanning, which can be challenging to achieve in practical settings. To overcome this limitation, we propose an innovative 3D conditional latent diffusion model (3D-CLDM) to generate high-quality NODDI index maps from low-resolution diffusion magnetic resonance imaging data. The 3D-CLDM is a two-stage super-resolved microstructure estimation model that includes training a vector quantized generative adversarial network and a diffusion model. It leverages the sophisticated high-dimensional data modeling capabilities of the conditional latent diffusion model to effectively capture and represent intricate microstructural features that are difficult to detect with conventional techniques. We conducted comprehensive experiments using data from the human connectome project to rigorously assess our model's performance. The results reveal that our approach not only significantly improves the quality of super-resolved microstructural estimation but also surpasses current state-of-the-art models in both qualitative and quantitative evaluations. This highlights the potential of 3D-CLDM to advance brain microstructure imaging, making it more feasible and effective for clinical applications.
KW - Conditional Diffusion Model
KW - Diffusion MRI
KW - Microstructural Imaging
KW - NODDI
UR - http://www.scopus.com/inward/record.url?scp=85217282583&partnerID=8YFLogxK
U2 - 10.1109/BIBM62325.2024.10822359
DO - 10.1109/BIBM62325.2024.10822359
M3 - 会议稿件
AN - SCOPUS:85217282583
T3 - Proceedings - 2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024
SP - 4247
EP - 4252
BT - Proceedings - 2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024
A2 - Cannataro, Mario
A2 - Zheng, Huiru
A2 - Gao, Lin
A2 - Cheng, Jianlin
A2 - de Miranda, Joao Luis
A2 - Zumpano, Ester
A2 - Hu, Xiaohua
A2 - Cho, Young-Rae
A2 - Park, Taesung
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024
Y2 - 3 December 2024 through 6 December 2024
ER -