Star-shaped poly(l -lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core: Synthesis, self-assembly, singlet oxygen research and recognition properties

Xiao Hui Dai; Zhi Ming Wang; Jian Ming Pan; Si Song Yuan; Yong Sheng Yan; Dong Ming Liu; Lin Sun

doi:10.1080/09205063.2014.946878

Star-shaped poly(l -lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core: Synthesis, self-assembly, singlet oxygen research and recognition properties

Xiao Hui Dai, Zhi Ming Wang, Jian Ming Pan, Si Song Yuan, Yong Sheng Yan, Dong Ming Liu, Lin Sun

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Star-shaped porphyrin-cored poly(l-lactide)-b-poly(lactobionamidoethyl methacrylate) block copolymers (SPPLA-b-PLAMA) were synthesized via RAFT of unprotected Lactobionamidoethyl methacrylate (LAMA) in 1-methyl-2-pyrrolidinone (NMP) solution at 70 °C. The structure of this as-synthesized SPPLA-b-PLAMA block copolymer was thoroughly studied by nuclear magnetic resonance spectroscopy, gel permeation chromatography (GPC), and Fourier transforms infrared. Moreover, under the irradiation, such SPPLA-b-PGAMA copolymer exhibits efficient singlet oxygen generation (0.17) and indicates high fluorescence quantum yields (0.20). Notably, with UV-vis investigation, SPPLA-b-PLAMA showed a very specific recognition with RCA₁₂₀ lectin. This will not only provide potentially prophyrin-cored star-shaped SPPLA-b-PLAMA block copolymers for targeted photodynamic therapy, but also improve the physical, biodegradation, biocompatibility properties of PLA-based biomaterials.

Original language	English
Pages (from-to)	1755-1770
Number of pages	16
Journal	Journal of Biomaterials Science, Polymer Edition
Volume	25
Issue number	16
DOIs	https://doi.org/10.1080/09205063.2014.946878
State	Published - Nov 2014
Externally published	Yes

Keywords

Copolymer
Porphyrin-cored
Recognition
Singlet oxygen generation

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10.1080/09205063.2014.946878

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Dai, X. H., Wang, Z. M., Pan, J. M., Yuan, S. S., Yan, Y. S., Liu, D. M., & Sun, L. (2014). Star-shaped poly(l -lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core: Synthesis, self-assembly, singlet oxygen research and recognition properties. Journal of Biomaterials Science, Polymer Edition, 25(16), 1755-1770. https://doi.org/10.1080/09205063.2014.946878

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title = "Star-shaped poly(l -lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core: Synthesis, self-assembly, singlet oxygen research and recognition properties",

abstract = "Star-shaped porphyrin-cored poly(l-lactide)-b-poly(lactobionamidoethyl methacrylate) block copolymers (SPPLA-b-PLAMA) were synthesized via RAFT of unprotected Lactobionamidoethyl methacrylate (LAMA) in 1-methyl-2-pyrrolidinone (NMP) solution at 70 °C. The structure of this as-synthesized SPPLA-b-PLAMA block copolymer was thoroughly studied by nuclear magnetic resonance spectroscopy, gel permeation chromatography (GPC), and Fourier transforms infrared. Moreover, under the irradiation, such SPPLA-b-PGAMA copolymer exhibits efficient singlet oxygen generation (0.17) and indicates high fluorescence quantum yields (0.20). Notably, with UV-vis investigation, SPPLA-b-PLAMA showed a very specific recognition with RCA120 lectin. This will not only provide potentially prophyrin-cored star-shaped SPPLA-b-PLAMA block copolymers for targeted photodynamic therapy, but also improve the physical, biodegradation, biocompatibility properties of PLA-based biomaterials.",

keywords = "Copolymer, Porphyrin-cored, Recognition, Singlet oxygen generation",

author = "Dai, {Xiao Hui} and Wang, {Zhi Ming} and Pan, {Jian Ming} and Yuan, {Si Song} and Yan, {Yong Sheng} and Liu, {Dong Ming} and Lin Sun",

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doi = "10.1080/09205063.2014.946878",

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Star-shaped poly(l -lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core: Synthesis, self-assembly, singlet oxygen research and recognition properties. / Dai, Xiao Hui; Wang, Zhi Ming; Pan, Jian Ming et al.
In: Journal of Biomaterials Science, Polymer Edition, Vol. 25, No. 16, 11.2014, p. 1755-1770.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Star-shaped poly(l -lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core

T2 - Synthesis, self-assembly, singlet oxygen research and recognition properties

AU - Dai, Xiao Hui

AU - Wang, Zhi Ming

AU - Pan, Jian Ming

AU - Yuan, Si Song

AU - Yan, Yong Sheng

AU - Liu, Dong Ming

AU - Sun, Lin

PY - 2014/11

Y1 - 2014/11

N2 - Star-shaped porphyrin-cored poly(l-lactide)-b-poly(lactobionamidoethyl methacrylate) block copolymers (SPPLA-b-PLAMA) were synthesized via RAFT of unprotected Lactobionamidoethyl methacrylate (LAMA) in 1-methyl-2-pyrrolidinone (NMP) solution at 70 °C. The structure of this as-synthesized SPPLA-b-PLAMA block copolymer was thoroughly studied by nuclear magnetic resonance spectroscopy, gel permeation chromatography (GPC), and Fourier transforms infrared. Moreover, under the irradiation, such SPPLA-b-PGAMA copolymer exhibits efficient singlet oxygen generation (0.17) and indicates high fluorescence quantum yields (0.20). Notably, with UV-vis investigation, SPPLA-b-PLAMA showed a very specific recognition with RCA120 lectin. This will not only provide potentially prophyrin-cored star-shaped SPPLA-b-PLAMA block copolymers for targeted photodynamic therapy, but also improve the physical, biodegradation, biocompatibility properties of PLA-based biomaterials.

AB - Star-shaped porphyrin-cored poly(l-lactide)-b-poly(lactobionamidoethyl methacrylate) block copolymers (SPPLA-b-PLAMA) were synthesized via RAFT of unprotected Lactobionamidoethyl methacrylate (LAMA) in 1-methyl-2-pyrrolidinone (NMP) solution at 70 °C. The structure of this as-synthesized SPPLA-b-PLAMA block copolymer was thoroughly studied by nuclear magnetic resonance spectroscopy, gel permeation chromatography (GPC), and Fourier transforms infrared. Moreover, under the irradiation, such SPPLA-b-PGAMA copolymer exhibits efficient singlet oxygen generation (0.17) and indicates high fluorescence quantum yields (0.20). Notably, with UV-vis investigation, SPPLA-b-PLAMA showed a very specific recognition with RCA120 lectin. This will not only provide potentially prophyrin-cored star-shaped SPPLA-b-PLAMA block copolymers for targeted photodynamic therapy, but also improve the physical, biodegradation, biocompatibility properties of PLA-based biomaterials.

KW - Copolymer

KW - Porphyrin-cored

KW - Recognition

KW - Singlet oxygen generation

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Star-shaped poly(l -lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core: Synthesis, self-assembly, singlet oxygen research and recognition properties

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