TY - JOUR
T1 - Solid-phase total synthesis and antimicrobial activities of loloatins A-D
AU - Ding, Yan
AU - Qin, Chuanguang
AU - Guo, Zhihong
AU - Niu, Weining
AU - Zhang, Ruijie
AU - Li, Yang
PY - 2007
Y1 - 2007
N2 - The first total synthesis of the decapeptide antibiotics loloatins A-D (1-4), originally isolated from the marine bacterial isolate MK-PNG-276A, possibly in the genus Bacillus, was accomplished by solid-phase peptide synthesis (SPPS), followed by 'head-to-tail' cyclization of the activated linear precursors, without protection of nucleophilic side-chain functions, on a safety-catch resin. The synthetic peptides were equally active as the natural products isolated from the bacterial source and found to possess similar bacterial selectivity as other members in the family of amphipathic antimicrobial cyclic decapeptides.
AB - The first total synthesis of the decapeptide antibiotics loloatins A-D (1-4), originally isolated from the marine bacterial isolate MK-PNG-276A, possibly in the genus Bacillus, was accomplished by solid-phase peptide synthesis (SPPS), followed by 'head-to-tail' cyclization of the activated linear precursors, without protection of nucleophilic side-chain functions, on a safety-catch resin. The synthetic peptides were equally active as the natural products isolated from the bacterial source and found to possess similar bacterial selectivity as other members in the family of amphipathic antimicrobial cyclic decapeptides.
UR - http://www.scopus.com/inward/record.url?scp=38049084035&partnerID=8YFLogxK
U2 - 10.1002/cbdv.200790232
DO - 10.1002/cbdv.200790232
M3 - 文章
C2 - 18081093
AN - SCOPUS:38049084035
SN - 1612-1872
VL - 4
SP - 2827
EP - 2834
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 12
ER -
