Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy

Runkai Lv; Zhengzheng Qian; Xiaopeng Zhao; Fei Xiong; Yingjie Xu; Wenpei Fan; Xikuang Yao; Wei Huang

doi:10.1007/s12274-022-5184-7

Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy

Runkai Lv, Zhengzheng Qian, Xiaopeng Zhao, Fei Xiong, Yingjie Xu, Wenpei Fan, Xikuang Yao, Wei Huang

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Polymer-induced self-assembly of inorganic nanoparticles has emerged as a powerful strategy for fabrication of stimuli-responsive drug delivery nanosystems. Herein, we designed and synthesized a series of lipoic acid-capped polysarcosine-b-polycaprolactone (PSar-b-PCL) block copolymers. The self-assembly of gold nanoparticles drove by these block copolymers was systematically investigated, and the preparation of near-infrared (NIR) light-responsive PSar-decorated gold nanovesicle (PSGV) was optimized. DOX as anticancer drug was efficiently encapsulated within the cavity of PSGV. The PSGV greatly prevented doxorubicin (DOX) from premature leakage. While upon 808 nm laser irradiation, most of loaded DOX was rapidly released, along with the recovery of DOX fluorescence. Impressively, the DOX-loaded PSGV (DOX-PSGV) exhibited much higher cell uptake efficiency when compared to DOX-loaded polyethylene glycol (PEG)-coated gold nanovesicle (DOX-PEGV). Thanks to the synergistic photothermal/chemo therapy, the DOX-PSGV had highly superior antitumor efficacy in established 4T1 tumor model. [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	5685-5694
Number of pages	10
Journal	Nano Research
Volume	16
Issue number	4
DOIs	https://doi.org/10.1007/s12274-022-5184-7
State	Published - Apr 2023
Externally published	Yes

Keywords

biodegradable copolymers
drug delivery system
gold nanovesicles
polymer-induced self-assembly
tumor therapy

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10.1007/s12274-022-5184-7

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title = "Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy",

abstract = "Polymer-induced self-assembly of inorganic nanoparticles has emerged as a powerful strategy for fabrication of stimuli-responsive drug delivery nanosystems. Herein, we designed and synthesized a series of lipoic acid-capped polysarcosine-b-polycaprolactone (PSar-b-PCL) block copolymers. The self-assembly of gold nanoparticles drove by these block copolymers was systematically investigated, and the preparation of near-infrared (NIR) light-responsive PSar-decorated gold nanovesicle (PSGV) was optimized. DOX as anticancer drug was efficiently encapsulated within the cavity of PSGV. The PSGV greatly prevented doxorubicin (DOX) from premature leakage. While upon 808 nm laser irradiation, most of loaded DOX was rapidly released, along with the recovery of DOX fluorescence. Impressively, the DOX-loaded PSGV (DOX-PSGV) exhibited much higher cell uptake efficiency when compared to DOX-loaded polyethylene glycol (PEG)-coated gold nanovesicle (DOX-PEGV). Thanks to the synergistic photothermal/chemo therapy, the DOX-PSGV had highly superior antitumor efficacy in established 4T1 tumor model. [Figure not available: see fulltext.]",

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author = "Runkai Lv and Zhengzheng Qian and Xiaopeng Zhao and Fei Xiong and Yingjie Xu and Wenpei Fan and Xikuang Yao and Wei Huang",

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T1 - Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy

AU - Lv, Runkai

AU - Qian, Zhengzheng

AU - Zhao, Xiaopeng

AU - Xiong, Fei

AU - Xu, Yingjie

AU - Fan, Wenpei

AU - Yao, Xikuang

AU - Huang, Wei

PY - 2023/4

Y1 - 2023/4

N2 - Polymer-induced self-assembly of inorganic nanoparticles has emerged as a powerful strategy for fabrication of stimuli-responsive drug delivery nanosystems. Herein, we designed and synthesized a series of lipoic acid-capped polysarcosine-b-polycaprolactone (PSar-b-PCL) block copolymers. The self-assembly of gold nanoparticles drove by these block copolymers was systematically investigated, and the preparation of near-infrared (NIR) light-responsive PSar-decorated gold nanovesicle (PSGV) was optimized. DOX as anticancer drug was efficiently encapsulated within the cavity of PSGV. The PSGV greatly prevented doxorubicin (DOX) from premature leakage. While upon 808 nm laser irradiation, most of loaded DOX was rapidly released, along with the recovery of DOX fluorescence. Impressively, the DOX-loaded PSGV (DOX-PSGV) exhibited much higher cell uptake efficiency when compared to DOX-loaded polyethylene glycol (PEG)-coated gold nanovesicle (DOX-PEGV). Thanks to the synergistic photothermal/chemo therapy, the DOX-PSGV had highly superior antitumor efficacy in established 4T1 tumor model. [Figure not available: see fulltext.]

AB - Polymer-induced self-assembly of inorganic nanoparticles has emerged as a powerful strategy for fabrication of stimuli-responsive drug delivery nanosystems. Herein, we designed and synthesized a series of lipoic acid-capped polysarcosine-b-polycaprolactone (PSar-b-PCL) block copolymers. The self-assembly of gold nanoparticles drove by these block copolymers was systematically investigated, and the preparation of near-infrared (NIR) light-responsive PSar-decorated gold nanovesicle (PSGV) was optimized. DOX as anticancer drug was efficiently encapsulated within the cavity of PSGV. The PSGV greatly prevented doxorubicin (DOX) from premature leakage. While upon 808 nm laser irradiation, most of loaded DOX was rapidly released, along with the recovery of DOX fluorescence. Impressively, the DOX-loaded PSGV (DOX-PSGV) exhibited much higher cell uptake efficiency when compared to DOX-loaded polyethylene glycol (PEG)-coated gold nanovesicle (DOX-PEGV). Thanks to the synergistic photothermal/chemo therapy, the DOX-PSGV had highly superior antitumor efficacy in established 4T1 tumor model. [Figure not available: see fulltext.]

KW - biodegradable copolymers

KW - drug delivery system

KW - gold nanovesicles

KW - polymer-induced self-assembly

KW - tumor therapy

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DO - 10.1007/s12274-022-5184-7

M3 - 文章

AN - SCOPUS:85141960478

SN - 1998-0124

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ER -

Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy

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Keywords

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