TY - JOUR
T1 - S100A10 might be a novel prognostic biomarker for head and neck squamous cell carcinoma based on bioinformatics analysis
AU - Gao, Shuo
AU - Zhang, Hao
AU - Lai, Linbin
AU - Zhang, Jiaqi
AU - Li, Yu
AU - Miao, Zhiping
AU - Rahman, Siddiq Ur
AU - Zhang, Honghao
AU - Qian, Airong
AU - Zhang, Wenjuan
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/10
Y1 - 2022/10
N2 - Head and neck squamous cell carcinoma (HNSCC) is a frequent malignant tumor of the head and neck with a dismal survival probability due to relapse and metastasis. S100As have been identified as being involved in the tumor procession of various cancer types. However, the expressions of S100As in HNSCC and their prognostic relevance are unknown. Bioinfromatics analysis was conducted to identify the prognostic value and function of S100As in HNSCC patients. In the study, we found that high mRNA expression levels of S100A3, S100A4, S100A7A, S100A9, and low mRNA expression levels of S100A1, S100A10 were related with a good overall survival in HNSCC patients. Importantly, the prognosis model suggested that S100A10 may have a certain impact on the development of HNSCC. Moreover, single-cell RNA sequencing analysis clarified that the specific functions of S100A10 had positive regulatory effects on metastasis, blood vessel generation, EMT, hypoxia, and invasion. Our findings implied that S100A10 might be a new prognostic biomarker for HNSCC, and played a role in promoting the occurrence, and development of HNSCC.
AB - Head and neck squamous cell carcinoma (HNSCC) is a frequent malignant tumor of the head and neck with a dismal survival probability due to relapse and metastasis. S100As have been identified as being involved in the tumor procession of various cancer types. However, the expressions of S100As in HNSCC and their prognostic relevance are unknown. Bioinfromatics analysis was conducted to identify the prognostic value and function of S100As in HNSCC patients. In the study, we found that high mRNA expression levels of S100A3, S100A4, S100A7A, S100A9, and low mRNA expression levels of S100A1, S100A10 were related with a good overall survival in HNSCC patients. Importantly, the prognosis model suggested that S100A10 may have a certain impact on the development of HNSCC. Moreover, single-cell RNA sequencing analysis clarified that the specific functions of S100A10 had positive regulatory effects on metastasis, blood vessel generation, EMT, hypoxia, and invasion. Our findings implied that S100A10 might be a new prognostic biomarker for HNSCC, and played a role in promoting the occurrence, and development of HNSCC.
KW - HNSCC
KW - Prognostic biomarker
KW - S100As
KW - Single cell sequencing
UR - http://www.scopus.com/inward/record.url?scp=85136737208&partnerID=8YFLogxK
U2 - 10.1016/j.compbiomed.2022.106000
DO - 10.1016/j.compbiomed.2022.106000
M3 - 文章
C2 - 36049414
AN - SCOPUS:85136737208
SN - 0010-4825
VL - 149
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
M1 - 106000
ER -
