TY - JOUR
T1 - Preparation of pH-responsive Fe3O4/Poly (acrylic acid-stat-methyl methacrylate-block-(2-dimethylamino) ethyl methacrylate) magnetic composite microspheres and its application in controlled release of drug
AU - Guo, Feige
AU - Zhang, Qiuyu
AU - Wang, Wenwen
AU - Zhang, Hepeng
AU - Sun, Jiuli
PY - 2011/7/20
Y1 - 2011/7/20
N2 - Controlled radical polymerization based on 1, 1-diphenylethylene (DPE method) was used to prepare pH-responsive magnetic composite microspheres. By this method, Fe3O4/Poly (acrylic acid-stat-methyl methacrylate-block-(2-dimethylamino) ethyl methacrylate) (Fe3O 4/P(AA-MMA-DMA)) microspheres were prepared via emulsifier free emulsion polymerization of acrylic acid (AA), methyl methacrylate (MMA) and (2-dimethylamino) ethyl methacrylate (DMA) using 1, 1-diphenylethylene (DPE) as radical control agent in the presence of Fe3O4 nanoparticles. The structure and properties of Fe3O4/P (AA-MMA-DMA) microspheres were characterized by IR, 1H NMR, SEC-MALLS, TEM, TGA, VSM and DLS. The application of Fe3O 4/P (AA-MMA-DMA) microspheres in controlled release of drug was also investigated. It was found that the DPE method allowed the preparation of pH-responsive magnetic composite microspheres, and Fe3O4/P (AA-MMA-DMA) microspheres obtained were pH-responsive, perfect sphere-shaped morphologies, superparamagnetism with a saturation magnetization of 14.36 emu/g, and high magnetic content with a value of 29%. Moreover, Fe3O 4/P (AA-MMA-DMA) microspheres could control the release of phenolphthalein in a buffer solution by adjusting the pH value.
AB - Controlled radical polymerization based on 1, 1-diphenylethylene (DPE method) was used to prepare pH-responsive magnetic composite microspheres. By this method, Fe3O4/Poly (acrylic acid-stat-methyl methacrylate-block-(2-dimethylamino) ethyl methacrylate) (Fe3O 4/P(AA-MMA-DMA)) microspheres were prepared via emulsifier free emulsion polymerization of acrylic acid (AA), methyl methacrylate (MMA) and (2-dimethylamino) ethyl methacrylate (DMA) using 1, 1-diphenylethylene (DPE) as radical control agent in the presence of Fe3O4 nanoparticles. The structure and properties of Fe3O4/P (AA-MMA-DMA) microspheres were characterized by IR, 1H NMR, SEC-MALLS, TEM, TGA, VSM and DLS. The application of Fe3O 4/P (AA-MMA-DMA) microspheres in controlled release of drug was also investigated. It was found that the DPE method allowed the preparation of pH-responsive magnetic composite microspheres, and Fe3O4/P (AA-MMA-DMA) microspheres obtained were pH-responsive, perfect sphere-shaped morphologies, superparamagnetism with a saturation magnetization of 14.36 emu/g, and high magnetic content with a value of 29%. Moreover, Fe3O 4/P (AA-MMA-DMA) microspheres could control the release of phenolphthalein in a buffer solution by adjusting the pH value.
KW - Controlled release
KW - DPE method
KW - Magnetic composite microsphere
KW - pH-responsive
KW - Preparation
UR - http://www.scopus.com/inward/record.url?scp=79956133398&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2011.02.014
DO - 10.1016/j.msec.2011.02.014
M3 - 文章
AN - SCOPUS:79956133398
SN - 0928-4931
VL - 31
SP - 938
EP - 944
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
IS - 5
ER -