Predicting functional cortical ROIs via joint modeling of anatomical and connectional profiles

Tuo Zhang, Dajiang Zhu, Xi Jiang, Lei Guo, Tianming Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Localization of functional cortical ROIs (regions of interests) in structural data such as DTI and T1-weighted MRI has significant importance in basic and clinical neuroscience. However, this problem is challenging due to the lack of quantitative mapping between brain structure and function, which relies on both the availability of benchmark training data such as task-based fMRI and effective machine learning algorithms. By using task-based fMRI derived ROIs as benchmarks, this paper presents a novel approach that develops predictive models of those ROIs based on concurrent DTI and T1-weighted MRI datasets within a machine learning paradigm. Particularly, in application stage, the predictive models are only applied on the structural datasets to predict functional ROI locations, which are evaluated by cross-validation studies, independent tests and reproducibility studies. We envision that these predictive models can be widely applied in scenarios that have only DTI and/or MRI data, but without task-based fMRI data.

Original languageEnglish
Title of host publicationISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro
Pages516-519
Number of pages4
DOIs
StatePublished - 2013
Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
Duration: 7 Apr 201311 Apr 2013

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
Country/TerritoryUnited States
CitySan Francisco, CA
Period7/04/1311/04/13

Keywords

  • connectivity
  • cortical landmarks
  • DTI
  • fMRI
  • T1-weighted MRI

Fingerprint

Dive into the research topics of 'Predicting functional cortical ROIs via joint modeling of anatomical and connectional profiles'. Together they form a unique fingerprint.

Cite this