Polymeric microneedles' swelling property characterizations using micro-optical coherence tomography

Xiaojun Yu, Razina Z. Seeni, Linbo Liu, Chenjie Xu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We report on noninvasive characterization of MNs' real-time swelling property in mice-skin using a lab-built micro-optical coherence tomography (µOCT). Specifically, we propose to encapsulate the iron-oxide (Fe3O4) nanoparticles into polymeric MNs as contrast agent to enhance OCT image contrast, and then evaluate its influences on contrast enhancement quantitatively. The MNs' real-time temporal swelling behaviors in mice-skin are recorded and analyzed. This is the first quantitative study on MNs' temporal swelling property in biological tissue using µOCT.

Original languageEnglish
Title of host publicationConference on Lasers and Electro-Optics/Pacific Rim, CLEOPR 2017
PublisherOptica Publishing Group (formerly OSA)
ISBN (Print)9781509062904
StatePublished - 2017
EventConference on Lasers and Electro-Optics/Pacific Rim, CLEOPR 2017 - Singapore, Singapore
Duration: 31 Jul 20174 Aug 2017

Publication series

NameOptics InfoBase Conference Papers
VolumePart F122-CLEOPR 2017
ISSN (Electronic)2162-2701

Conference

ConferenceConference on Lasers and Electro-Optics/Pacific Rim, CLEOPR 2017
Country/TerritorySingapore
CitySingapore
Period31/07/174/08/17

Keywords

  • Contrast agent
  • Iron oxide nanoparticles
  • Microneedles
  • OCT
  • Swelling imaging

Fingerprint

Dive into the research topics of 'Polymeric microneedles' swelling property characterizations using micro-optical coherence tomography'. Together they form a unique fingerprint.

Cite this