Photo-controlled host-guest interaction as a new strategy to improve the preparation of "breathing" hollow polymer nanospheres for controlled drug delivery

Haitao Zhang; Wei Tian; Rongtian Suo; Yang Yue; Xiaodong Fan; Zhen Yang; Hui Li; Wanbin Zhang; Yang Bai

doi:10.1039/c5tb01665g

Photo-controlled host-guest interaction as a new strategy to improve the preparation of "breathing" hollow polymer nanospheres for controlled drug delivery

Haitao Zhang, Wei Tian, Rongtian Suo, Yang Yue, Xiaodong Fan, Zhen Yang, Hui Li, Wanbin Zhang, Yang Bai

School of Chemistry and Chemical Engineering

Northwestern Polytechnical University Xian

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

This paper presents the photo-controlled host-guest interaction between azobenzene and β-cyclodextrin as a new strategy to improve the method of core removal to prepare poly((itaconoyloxy)ethyl methacrylate)-block-poly(N-isopropylacrylamide)-based hollow nanospheres. This improved method for the preparation of hollow nanospheres is simple, environmentally friendly, and highly efficient. The resulting hollow nanospheres displayed a typical "breathing" behavior, which further induces the controlled release of doxorubicin hydrochloride. Cellular toxicity evaluation indicated that the hollow nanospheres possess good biocompatibility and can be used as promising doxorubicin hydrochloride carriers.

Original language	English
Pages (from-to)	8528-8536
Number of pages	9
Journal	Journal of Materials Chemistry B
Volume	3
Issue number	43
DOIs	https://doi.org/10.1039/c5tb01665g
State	Published - 23 Sep 2015

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abstract = "This paper presents the photo-controlled host-guest interaction between azobenzene and β-cyclodextrin as a new strategy to improve the method of core removal to prepare poly((itaconoyloxy)ethyl methacrylate)-block-poly(N-isopropylacrylamide)-based hollow nanospheres. This improved method for the preparation of hollow nanospheres is simple, environmentally friendly, and highly efficient. The resulting hollow nanospheres displayed a typical {"}breathing{"} behavior, which further induces the controlled release of doxorubicin hydrochloride. Cellular toxicity evaluation indicated that the hollow nanospheres possess good biocompatibility and can be used as promising doxorubicin hydrochloride carriers.",

author = "Haitao Zhang and Wei Tian and Rongtian Suo and Yang Yue and Xiaodong Fan and Zhen Yang and Hui Li and Wanbin Zhang and Yang Bai",

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AU - Zhang, Haitao

AU - Tian, Wei

AU - Suo, Rongtian

AU - Yue, Yang

AU - Fan, Xiaodong

AU - Yang, Zhen

AU - Li, Hui

AU - Zhang, Wanbin

AU - Bai, Yang

PY - 2015/9/23

Y1 - 2015/9/23

N2 - This paper presents the photo-controlled host-guest interaction between azobenzene and β-cyclodextrin as a new strategy to improve the method of core removal to prepare poly((itaconoyloxy)ethyl methacrylate)-block-poly(N-isopropylacrylamide)-based hollow nanospheres. This improved method for the preparation of hollow nanospheres is simple, environmentally friendly, and highly efficient. The resulting hollow nanospheres displayed a typical "breathing" behavior, which further induces the controlled release of doxorubicin hydrochloride. Cellular toxicity evaluation indicated that the hollow nanospheres possess good biocompatibility and can be used as promising doxorubicin hydrochloride carriers.

AB - This paper presents the photo-controlled host-guest interaction between azobenzene and β-cyclodextrin as a new strategy to improve the method of core removal to prepare poly((itaconoyloxy)ethyl methacrylate)-block-poly(N-isopropylacrylamide)-based hollow nanospheres. This improved method for the preparation of hollow nanospheres is simple, environmentally friendly, and highly efficient. The resulting hollow nanospheres displayed a typical "breathing" behavior, which further induces the controlled release of doxorubicin hydrochloride. Cellular toxicity evaluation indicated that the hollow nanospheres possess good biocompatibility and can be used as promising doxorubicin hydrochloride carriers.

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DO - 10.1039/c5tb01665g

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JO - Journal of Materials Chemistry B

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Photo-controlled host-guest interaction as a new strategy to improve the preparation of "breathing" hollow polymer nanospheres for controlled drug delivery

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