TY - JOUR
T1 - Perylene Diimide-Grafted Polymeric Nanoparticles Chelated with Gd3+ for Photoacoustic/T1-Weighted Magnetic Resonance Imaging-Guided Photothermal Therapy
AU - Hu, Xiaoming
AU - Lu, Feng
AU - Chen, Liang
AU - Tang, Yufu
AU - Hu, Wenbo
AU - Lu, Xiaomei
AU - Ji, Yu
AU - Yang, Zhen
AU - Zhang, Wansu
AU - Yin, Chao
AU - Huang, Wei
AU - Fan, Quli
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/9/13
Y1 - 2017/9/13
N2 - Developing versatile and easily prepared nanomaterials with both imaging and therapeutic properties have received significant attention in cancer diagnostics and therapeutics. Here, we facilely fabricated Gd3+-chelated poly(isobutylene-alt-maleic anhydride) (PMA) framework pendent with perylene-3,4,9,10-tetracarboxylic diimide (PDI) derivatives and poly(ethylene glycol) (PEG) as an efficient theranostic platform for dual-modal photoacoustic imaging (PAI) and magnetic resonance imaging (MRI)-guided photothermal therapy. The obtained polymeric nanoparticles (NPs) chelated with Gd3+ (PMA-PDI-PEG-Gd NPs) exhibited a high T1 relaxivity coefficient (13.95 mM-1 s-1) even at the higher magnetic fields. After 3.5 h of tail vein injection of PMA-PDI-PEG-Gd NPs, the tumor areas showed conspicuous enhancement in both photoacoustic signal and T1-weighted MRI intensity, indicating the efficient accumulation of PMA-PDI-PEG-Gd NPs owing to the enhanced permeation and retention effect. In addition, the excellent tumor ablation therapeutic effect in vivo was demonstrated with living mice. Overall, our work illustrated a straightforward synthetic strategy for engineering multifunctional polymeric nanoparticles for dual-modal imaging to obtain more accurate information for efficient diagnosis and therapy.
AB - Developing versatile and easily prepared nanomaterials with both imaging and therapeutic properties have received significant attention in cancer diagnostics and therapeutics. Here, we facilely fabricated Gd3+-chelated poly(isobutylene-alt-maleic anhydride) (PMA) framework pendent with perylene-3,4,9,10-tetracarboxylic diimide (PDI) derivatives and poly(ethylene glycol) (PEG) as an efficient theranostic platform for dual-modal photoacoustic imaging (PAI) and magnetic resonance imaging (MRI)-guided photothermal therapy. The obtained polymeric nanoparticles (NPs) chelated with Gd3+ (PMA-PDI-PEG-Gd NPs) exhibited a high T1 relaxivity coefficient (13.95 mM-1 s-1) even at the higher magnetic fields. After 3.5 h of tail vein injection of PMA-PDI-PEG-Gd NPs, the tumor areas showed conspicuous enhancement in both photoacoustic signal and T1-weighted MRI intensity, indicating the efficient accumulation of PMA-PDI-PEG-Gd NPs owing to the enhanced permeation and retention effect. In addition, the excellent tumor ablation therapeutic effect in vivo was demonstrated with living mice. Overall, our work illustrated a straightforward synthetic strategy for engineering multifunctional polymeric nanoparticles for dual-modal imaging to obtain more accurate information for efficient diagnosis and therapy.
KW - gadolinium ion
KW - magnetic resonance imaging
KW - multifunctional polymeric nanoparticle
KW - photoacoustic imaging
KW - photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85029430417&partnerID=8YFLogxK
U2 - 10.1021/acsami.7b09633
DO - 10.1021/acsami.7b09633
M3 - 文章
C2 - 28825456
AN - SCOPUS:85029430417
SN - 1944-8244
VL - 9
SP - 30458
EP - 30469
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 36
ER -
