Non-gaussian dynamics of a tumor growth system with immunization

Mengli Hao, Ting Gao, Jinqiao Duan, Wei Xu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This paper is devoted to exploring the effects of non-Gaussian fluctuations on dynamical evolution of a tumor growth model with immunization, subject to non-Gaussian α-stable type Lévy noise. The corresponding deterministic model has two meaningful states which represent the state of tumor extinction and the state of stable tumor, respectively. To characterize the time for different initial densities of tumor cells staying in the domain between these two states and the likelihood of crossing this domain, the mean exit time and the escape probability are quantified by numerically solving differential-integral equations with appropriate exterior boundary conditions. The relationships between the dynamical properties and the noise parameters are examined. It is found that in the different stages of tumor, the noise parameters have different influences on the time and the likelihood inducing tumor extinction. These results are relevant for determining efficient therapeutic regimes to induce the extinction of tumor cells.

Original languageEnglish
Pages (from-to)697-716
Number of pages20
JournalInverse Problems and Imaging
Volume7
Issue number3
DOIs
StatePublished - Aug 2013

Keywords

  • Escape probability
  • Lévy jump measure
  • Mean exit time
  • Non-Gaussian Lévy process
  • Stochastic dynamics of tumor growth
  • Tumor growth with immunization

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