Multilayered Scaffold with a Compact Interfacial Layer Enhances Osteochondral Defect Repair

Shuaijun Jia, Jing Wang, Ting Zhang, Weimin Pan, Zhong Li, Xin He, Chongfei Yang, Qining Wu, Wei Sun, Zhuo Xiong, Dingjun Hao

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Repairing osteochondral defect (OCD) using advanced biomaterials that structurally, biologically, and mechanically fulfill the criteria for stratified tissue regeneration remains a significant challenge for researchers. Here, a multilayered scaffold (MLS) with hierarchical organization and heterogeneous composition is developed to mimic the stratified structure and complex components of natural osteochondral tissues. Specifically, the intermediate compact interfacial layer within the MLS is designed to resemble the osteochondral interface to realize the closely integrated layered structure. Subsequently, macroscopic observations, histological evaluation, and biomechanical and biochemical assessments are performed to evaluate the ability of the MLS of repairing OCD in a goat model. By 48 weeks postimplantation, superior hyalinelike cartilage and sound subchondral bone are observed in the MLS group. Furthermore, the biomimetic MLS significantly enhances the biomechanical and biochemical properties of the neo-osteochondral tissue. Taken together, these results confirm the potential of this optimized MLS as an advanced strategy for OCD repair.

Original languageEnglish
Pages (from-to)20296-20305
Number of pages10
JournalACS Applied Materials and Interfaces
Volume10
Issue number24
DOIs
StatePublished - 20 Jun 2018

Keywords

  • goat model
  • multilayered scaffold
  • osteochondral defect
  • osteochondral interface
  • tissue engineering

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