TY - JOUR
T1 - Multilayered Scaffold with a Compact Interfacial Layer Enhances Osteochondral Defect Repair
AU - Jia, Shuaijun
AU - Wang, Jing
AU - Zhang, Ting
AU - Pan, Weimin
AU - Li, Zhong
AU - He, Xin
AU - Yang, Chongfei
AU - Wu, Qining
AU - Sun, Wei
AU - Xiong, Zhuo
AU - Hao, Dingjun
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/6/20
Y1 - 2018/6/20
N2 - Repairing osteochondral defect (OCD) using advanced biomaterials that structurally, biologically, and mechanically fulfill the criteria for stratified tissue regeneration remains a significant challenge for researchers. Here, a multilayered scaffold (MLS) with hierarchical organization and heterogeneous composition is developed to mimic the stratified structure and complex components of natural osteochondral tissues. Specifically, the intermediate compact interfacial layer within the MLS is designed to resemble the osteochondral interface to realize the closely integrated layered structure. Subsequently, macroscopic observations, histological evaluation, and biomechanical and biochemical assessments are performed to evaluate the ability of the MLS of repairing OCD in a goat model. By 48 weeks postimplantation, superior hyalinelike cartilage and sound subchondral bone are observed in the MLS group. Furthermore, the biomimetic MLS significantly enhances the biomechanical and biochemical properties of the neo-osteochondral tissue. Taken together, these results confirm the potential of this optimized MLS as an advanced strategy for OCD repair.
AB - Repairing osteochondral defect (OCD) using advanced biomaterials that structurally, biologically, and mechanically fulfill the criteria for stratified tissue regeneration remains a significant challenge for researchers. Here, a multilayered scaffold (MLS) with hierarchical organization and heterogeneous composition is developed to mimic the stratified structure and complex components of natural osteochondral tissues. Specifically, the intermediate compact interfacial layer within the MLS is designed to resemble the osteochondral interface to realize the closely integrated layered structure. Subsequently, macroscopic observations, histological evaluation, and biomechanical and biochemical assessments are performed to evaluate the ability of the MLS of repairing OCD in a goat model. By 48 weeks postimplantation, superior hyalinelike cartilage and sound subchondral bone are observed in the MLS group. Furthermore, the biomimetic MLS significantly enhances the biomechanical and biochemical properties of the neo-osteochondral tissue. Taken together, these results confirm the potential of this optimized MLS as an advanced strategy for OCD repair.
KW - goat model
KW - multilayered scaffold
KW - osteochondral defect
KW - osteochondral interface
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85047979476&partnerID=8YFLogxK
U2 - 10.1021/acsami.8b03445
DO - 10.1021/acsami.8b03445
M3 - 文章
C2 - 29808989
AN - SCOPUS:85047979476
SN - 1944-8244
VL - 10
SP - 20296
EP - 20305
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 24
ER -