Multi-scale and multimodal fusion of tract-tracing, myelin stain and DTI-derived fibers in macaque brains

Tuo Zhang, Jun Kong, Ke Jing, Hanbo Chen, Xi Jiang, Longchuan Li, Lei Guo, Jianfeng Lu, Xiaoping Hu, Tianming Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

Assessment of structural connectivity patterns of brains can be an important avenue for better understanding mechanisms of structural and functional brain architectures. Therefore, many efforts have been made to estimate and validate axonal pathways via a number of techniques, such as myelin stain, tract-tracing and diffusion MRI (dMRI). The three modalities have their own advantages and are complimentary to each other. From myelin stain data, we can infer rich in-plane information of axonal orientation at micro-scale. Tracttracing data is considered as ‘gold standard’ to estimate trustworthy meso-scale pathways. dMRI currently is the only way to estimate global macro-scale pathways given further validation. We propose a framework to take advantage of these three modalities. Information of the three modalities is integrated to determine the optimal tractography parameters for dMRI fibers and identify crossvalidated fiber bundles that are finally used to construct atlas. We demonstrate the effectiveness of the framework by a collection of experimental results.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2015 - 18th International Conference, Proceedings
EditorsJoachim Hornegger, Alejandro F. Frangi, William M. Wells, Alejandro F. Frangi, Nassir Navab, Joachim Hornegger, Nassir Navab, William M. Wells, William M. Wells, Alejandro F. Frangi, Joachim Hornegger, Nassir Navab
PublisherSpringer Verlag
Pages246-254
Number of pages9
ISBN (Print)9783319245706, 9783319245706, 9783319245706
DOIs
StatePublished - 2015
Event18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015 - Munich, Germany
Duration: 5 Oct 20159 Oct 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9350
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015
Country/TerritoryGermany
CityMunich
Period5/10/159/10/15

Keywords

  • Atlas
  • DTI
  • Multi-scale and multimodal fusion
  • Myelin stain
  • Tract-tracing

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