Most probable trajectories in a two-dimensional tumor-immune system under stochastic perturbation

Ping Han, Wei Xu, Liang Wang, Hongxia Zhang, Zhicong Ren

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

This paper investigates the most probable trajectories of the stochastic two-dimensional tumor-immune system. It is worth mentioning that the most probable trajectories are a deterministic indicator for researching stochastic systems, and its role is analogous to the phase diagram and time history diagram of deterministic systems. Firstly, the effects of system parameters on dynamical behavior of the deterministic system are analyzed. Next, the stochastic system is introduced to explore the most probable trajectories under the known initial conditions and boundary conditions. Finally, given initial conditions, we can conclude that the tumor growth rate and the immune cell death rate (greater than 0.1) suppress the extinction of tumor cells, while the source rate of the immune cell and the stochastic parameters facilitate tumor cells apoptosis, which is beneficial to host health. Further, the stochastic parameters are also conducive to health under the known boundary conditions, which is exactly what we expect.

Original languageEnglish
Pages (from-to)800-814
Number of pages15
JournalApplied Mathematical Modelling
Volume105
DOIs
StatePublished - May 2022

Keywords

  • Most probable trajectories
  • Multiplicative Gaussian noises
  • Onsager-Machlup functional
  • Probability density function
  • Two-dimensional tumor-immune system

Fingerprint

Dive into the research topics of 'Most probable trajectories in a two-dimensional tumor-immune system under stochastic perturbation'. Together they form a unique fingerprint.

Cite this