TY - JOUR
T1 - Moderate Static Magnetic Fields Prevent Bone Architectural Deterioration and Strength Reduction in Ovariectomized Mice
AU - Yang, Jiancheng
AU - Zhou, Shaojie
AU - Wei, Min
AU - Fang, Yanwen
AU - Shang, Peng
N1 - Publisher Copyright:
© 1965-2012 IEEE.
PY - 2021/7
Y1 - 2021/7
N2 - Substantial studies have revealed the capacity of moderate-intensity static magnetic fields (SMFs) on promoting osteogenesis and inhibiting bone resorption. However, it is unknown whether moderate SMF can resist the deterioration of bone microarchitecture and strength induced by the reduction of estrogen in animal model for postmenopausal osteoporosis. Herein, the efficiency of moderate SMF of 0.20.4 T and SMF of 0.6 T on bone mineral density (BMD) and bone mineral content (BMC), bone microarchitecture, bone strength, and histological bone turnover was systematically investigated in ovariectomized (OVX) mice. OVX mice and sham mice were subjected to SMF exposure continuously for four weeks. Dual-energy X-ray absorptiometry (DEXA) data showed SMF prevented the reduction of BMD and BMC in OVX mice. Micro-computed tomography (Micro-CT) results revealed that SMF ameliorated the deterioration of trabecular and cortical bone microarchitecture. Three-point bending test showed that SMF mitigated OVX-induced reduction in femoral mechanical properties, including stiffness, ultimate stress, and elasticity modulus. Moreover, bone histochemical analysis demonstrated that SMF decreased osteoclast formation in cancellous bone and cortical bone, while SMF increased osteoblast formation in trabecular bone. Together, these results demonstrate that moderate SMF alleviated menopause-induced bone loss effectively, and imply that moderate SMF might become a potential biophysical treatment modality for postmenopausal osteoporosis.
AB - Substantial studies have revealed the capacity of moderate-intensity static magnetic fields (SMFs) on promoting osteogenesis and inhibiting bone resorption. However, it is unknown whether moderate SMF can resist the deterioration of bone microarchitecture and strength induced by the reduction of estrogen in animal model for postmenopausal osteoporosis. Herein, the efficiency of moderate SMF of 0.20.4 T and SMF of 0.6 T on bone mineral density (BMD) and bone mineral content (BMC), bone microarchitecture, bone strength, and histological bone turnover was systematically investigated in ovariectomized (OVX) mice. OVX mice and sham mice were subjected to SMF exposure continuously for four weeks. Dual-energy X-ray absorptiometry (DEXA) data showed SMF prevented the reduction of BMD and BMC in OVX mice. Micro-computed tomography (Micro-CT) results revealed that SMF ameliorated the deterioration of trabecular and cortical bone microarchitecture. Three-point bending test showed that SMF mitigated OVX-induced reduction in femoral mechanical properties, including stiffness, ultimate stress, and elasticity modulus. Moreover, bone histochemical analysis demonstrated that SMF decreased osteoclast formation in cancellous bone and cortical bone, while SMF increased osteoblast formation in trabecular bone. Together, these results demonstrate that moderate SMF alleviated menopause-induced bone loss effectively, and imply that moderate SMF might become a potential biophysical treatment modality for postmenopausal osteoporosis.
KW - Bone mechanical properties
KW - bone microarchitecture
KW - bone remodeling
KW - osteoporosis
KW - static magnetic fields (SMFs)
UR - http://www.scopus.com/inward/record.url?scp=85104190999&partnerID=8YFLogxK
U2 - 10.1109/TMAG.2021.3072148
DO - 10.1109/TMAG.2021.3072148
M3 - 文章
AN - SCOPUS:85104190999
SN - 0018-9464
VL - 57
JO - IEEE Transactions on Magnetics
JF - IEEE Transactions on Magnetics
IS - 7
M1 - 9399486
ER -