TY - JOUR
T1 - Microstructures and mechanical properties of biphasic calcium phosphate bioceramics fabricated by SLA 3D printing
AU - Dong, Dong
AU - Su, Haijun
AU - Li, Xiang
AU - Fan, Guangrao
AU - Zhao, Di
AU - Shen, Zhonglin
AU - Liu, Yuan
AU - Guo, Yinuo
AU - Yang, Chubin
AU - Liu, Lin
AU - Fu, Hengzhi
N1 - Publisher Copyright:
© 2022 The Society of Manufacturing Engineers
PY - 2022/9
Y1 - 2022/9
N2 - Porous biphasic calcium phosphate (BCP) bioceramics are considered to be the most promising bone repair materials in clinical medicine. Stereolithography (SLA) 3D printing can precisely fabricate bioceramic scaffolds with complex porous structure. During this process, how to obtain a suitable sintering procedure for BCP bioceramics by SLA 3D printing is the key to determine the microstructures and mechanical properties, but this is absent. In this present study, we prepared BCP bioceramics with superior densification and mechanical properties by SLA 3D printing, and mainly investigated the effects of sintering temperature and condition on the microstructures and mechanical properties of SLA 3D printed BCP bioceramics for the first time. At the optimized procedure of sintering temperature 1250 °C for 2 h, the 3D printed BCP bioceramics showed uniform shrinkage in all directions, and especially the mechanical properties were close to that of human cortical bone. Furthermore, complex porous BCP scaffolds with high porosity (51.49 %) and compressive strength (8.14 MPa) were successfully obtained. BCP bioceramics greatly promoted the proliferation of MC3T3-E1 cells by the release of Ca and P ion and presented excellent bioactivity. This work proves that SLA 3D printing technology can prepare BCP bioceramics with high mechanical and functional properties, and provides a new route for manufacturing high performance BCP bioceramic scaffolds with complex structure by SLA 3D printing for repairing bone defect in clinical.
AB - Porous biphasic calcium phosphate (BCP) bioceramics are considered to be the most promising bone repair materials in clinical medicine. Stereolithography (SLA) 3D printing can precisely fabricate bioceramic scaffolds with complex porous structure. During this process, how to obtain a suitable sintering procedure for BCP bioceramics by SLA 3D printing is the key to determine the microstructures and mechanical properties, but this is absent. In this present study, we prepared BCP bioceramics with superior densification and mechanical properties by SLA 3D printing, and mainly investigated the effects of sintering temperature and condition on the microstructures and mechanical properties of SLA 3D printed BCP bioceramics for the first time. At the optimized procedure of sintering temperature 1250 °C for 2 h, the 3D printed BCP bioceramics showed uniform shrinkage in all directions, and especially the mechanical properties were close to that of human cortical bone. Furthermore, complex porous BCP scaffolds with high porosity (51.49 %) and compressive strength (8.14 MPa) were successfully obtained. BCP bioceramics greatly promoted the proliferation of MC3T3-E1 cells by the release of Ca and P ion and presented excellent bioactivity. This work proves that SLA 3D printing technology can prepare BCP bioceramics with high mechanical and functional properties, and provides a new route for manufacturing high performance BCP bioceramic scaffolds with complex structure by SLA 3D printing for repairing bone defect in clinical.
KW - Bioceramics
KW - Biphasic calcium phosphates
KW - Mechanical properties
KW - Sintering process
KW - SLA 3D printing
UR - http://www.scopus.com/inward/record.url?scp=85134220024&partnerID=8YFLogxK
U2 - 10.1016/j.jmapro.2022.07.016
DO - 10.1016/j.jmapro.2022.07.016
M3 - 文章
AN - SCOPUS:85134220024
SN - 1526-6125
VL - 81
SP - 433
EP - 443
JO - Journal of Manufacturing Processes
JF - Journal of Manufacturing Processes
ER -