MicroRNAs and Osteoarthritis

Shenxing Tan, Qian Huang, Xuechao Liang, Ye Tian, Airong Qian

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Osteoarthritis (OA) is the most common joint disease. It is characterized by degenerative changes of articular cartilage and chondrocyte apoptosis. The prevalence of OA increases with age and affects most individuals over the age of 65. However, due to the various influencing factors and complicated molecular mechanisms of OA pathogenesis, at present, there is no effective method to cure OA except total joint replacement surgery. Interventions could be taken to slow the progression of OA and prevent the irreversible degradation of cartilage. MicroRNAs (miRNAs) are endogenous noncoding single-stranded small molecule RNAs, which involve in a series of important processes in life. In recent years, more and more researchers have found that many miRNAs are inseparable from the occurrence of OA. This chapter mainly focuses on summarizing those microRNAs which participate in the occurrence and development of OA (e.g., the proliferation and apoptosis of chondrocytes, the degenerative changes of articular cartilage extracellular matrix (ECM), the process of chondrocyte inflammation and joint pain) as well as the related signal regulation pathways. We will discuss the latest research progress of microRNA in the treatment of OA and provide new insights into potential molecular targets for the prevention and treatment of OA.

Original languageEnglish
Title of host publicationNoncoding RNAs and Bone
PublisherSpringer Singapore
Pages47-77
Number of pages31
ISBN (Electronic)9789811624025
ISBN (Print)9789811624018
DOIs
StatePublished - 1 Jan 2021

Keywords

  • Chondrocyte inflammation
  • Chondrocytes
  • ECM
  • Joint pain
  • MicroRNAs
  • Osteoarthritis
  • Pathways

Fingerprint

Dive into the research topics of 'MicroRNAs and Osteoarthritis'. Together they form a unique fingerprint.

Cite this