MFCluster: Mining maximal fault-tolerant constant row biclusters in microarray dataset

Miao Wang, Xuequn Shang, Miao Miao, Zhanhuai Li, Wenbin Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Biclustering is one of the most popular methods for microarray dataset analysis, which allows for conditions and genes clustering simultaneously. However, due to the influence of experimental noise in the microarray dataset, using traditional biclustering methods may neglect some significative biological biclusters. In order to reduce the influence of noise and find more types of biological biclusters, we propose an algorithm, MFCluster, to mine fault-tolerant biclusters in microarray dataset. MFCluster uses several novel techniques to generate fault-tolerant efficiently by merging non-relaxed biclusters. MFCluster generates a weighted undirected relational graph firstly. Then all the maximal fault-tolerant biclusters would be mined by using pattern-growth method in above graph. The experimental results show our algorithm is more efficiently than traditional ones.

Original languageEnglish
Title of host publicationWeb-Age Information Management - 12th International Conference,WAIM 2011, Proceedings
Pages181-190
Number of pages10
DOIs
StatePublished - 2011
Event12th International Conference on Web-Age Information Management, WAIM 2011 - Wuhan, China
Duration: 14 Sep 201116 Sep 2011

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6897 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference12th International Conference on Web-Age Information Management, WAIM 2011
Country/TerritoryChina
CityWuhan
Period14/09/1116/09/11

Keywords

  • bicluster
  • constant row
  • fault-tolerant
  • microarray

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