Isoforms, structures, and functions of versatile spectraplakin MACF1

Lifang Hu; Peihong Su; Runzhi Li; Chong Yin; Yan Zhang; Peng Shang; Tuanmin Yang; Airong Qian

doi:10.5483/BMBRep.2016.49.1.185

Isoforms, structures, and functions of versatile spectraplakin MACF1

Lifang Hu, Peihong Su, Runzhi Li, Chong Yin, Yan Zhang, Peng Shang, Tuanmin Yang, Airong Qian

School of life sciences

Research output: Contribution to journal › Short survey › peer-review

38 Scopus citations

Abstract

Spectraplakins are crucially important communicators, linking cytoskeletal components to each other and cellular junctions. Microtubule actin crosslinking factor 1 (MACF1), also known as actin crosslinking family 7 (ACF7), is a member of the spectraplakin family. It is expressed in numerous tissues and cells as one extensively studied spectraplakin. MACF1 has several isoforms with unique structures and well-known function to be able to crosslink F-actin and microtubules. MACF1 is one versatile spectraplakin with various functions in cell processes, embryo development, tissue-specific functions, and human diseases. The importance of MACF1 has become more apparent in recent years. Here, we summarize the current knowledge on the presence and function of MACF1 and provide perspectives on future research of MACF1 based on our studies and others.

Original language	English
Pages (from-to)	37-44
Number of pages	8
Journal	BMB Reports
Volume	49
Issue number	1
DOIs	https://doi.org/10.5483/BMBRep.2016.49.1.185
State	Published - 2016

Keywords

Function
Isoform
MACF1
Spectraplakin
Structure

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5483/BMBRep.2016.49.1.185

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title = "Isoforms, structures, and functions of versatile spectraplakin MACF1",

abstract = "Spectraplakins are crucially important communicators, linking cytoskeletal components to each other and cellular junctions. Microtubule actin crosslinking factor 1 (MACF1), also known as actin crosslinking family 7 (ACF7), is a member of the spectraplakin family. It is expressed in numerous tissues and cells as one extensively studied spectraplakin. MACF1 has several isoforms with unique structures and well-known function to be able to crosslink F-actin and microtubules. MACF1 is one versatile spectraplakin with various functions in cell processes, embryo development, tissue-specific functions, and human diseases. The importance of MACF1 has become more apparent in recent years. Here, we summarize the current knowledge on the presence and function of MACF1 and provide perspectives on future research of MACF1 based on our studies and others.",

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author = "Lifang Hu and Peihong Su and Runzhi Li and Chong Yin and Yan Zhang and Peng Shang and Tuanmin Yang and Airong Qian",

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year = "2016",

doi = "10.5483/BMBRep.2016.49.1.185",

language = "英语",

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T1 - Isoforms, structures, and functions of versatile spectraplakin MACF1

AU - Hu, Lifang

AU - Su, Peihong

AU - Li, Runzhi

AU - Yin, Chong

AU - Zhang, Yan

AU - Shang, Peng

AU - Yang, Tuanmin

AU - Qian, Airong

PY - 2016

Y1 - 2016

N2 - Spectraplakins are crucially important communicators, linking cytoskeletal components to each other and cellular junctions. Microtubule actin crosslinking factor 1 (MACF1), also known as actin crosslinking family 7 (ACF7), is a member of the spectraplakin family. It is expressed in numerous tissues and cells as one extensively studied spectraplakin. MACF1 has several isoforms with unique structures and well-known function to be able to crosslink F-actin and microtubules. MACF1 is one versatile spectraplakin with various functions in cell processes, embryo development, tissue-specific functions, and human diseases. The importance of MACF1 has become more apparent in recent years. Here, we summarize the current knowledge on the presence and function of MACF1 and provide perspectives on future research of MACF1 based on our studies and others.

AB - Spectraplakins are crucially important communicators, linking cytoskeletal components to each other and cellular junctions. Microtubule actin crosslinking factor 1 (MACF1), also known as actin crosslinking family 7 (ACF7), is a member of the spectraplakin family. It is expressed in numerous tissues and cells as one extensively studied spectraplakin. MACF1 has several isoforms with unique structures and well-known function to be able to crosslink F-actin and microtubules. MACF1 is one versatile spectraplakin with various functions in cell processes, embryo development, tissue-specific functions, and human diseases. The importance of MACF1 has become more apparent in recent years. Here, we summarize the current knowledge on the presence and function of MACF1 and provide perspectives on future research of MACF1 based on our studies and others.

KW - Function

KW - Isoform

KW - MACF1

KW - Spectraplakin

KW - Structure

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Isoforms, structures, and functions of versatile spectraplakin MACF1

Abstract

Keywords

UN SDGs

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