Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro

Yuqing Duan; Haihui Zhang; Feifei Xu; Bijun Xie; Xianwen Yang; Yong Wang; Yongsheng Yan

doi:10.1016/j.foodchem.2010.02.020

Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro

Yuqing Duan, Haihui Zhang, Feifei Xu, Bijun Xie, Xianwen Yang, Yong Wang, Yongsheng Yan

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Significant growth inhibition effects of procyanidins from lotus (Nelumbo nucifera Gaertn.) seedpod (LSPCs) on mouse melanoma B16 were found both in vivo and in vitro. In vivo treatment with LSPCs inhibited tumour growth in C₅₇BL/6 J mice by 55.3% in terms of average tumour weight. LSPCs can significantly (P < 0.05) decrease lipid peroxidation (LPO) levels and increase the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in liver tissue. In vitro assay of anti-cancer activities suggested that LSPCs (25-100 μg/ml) possessed cytotoxicities against mouse melanoma B16 in a dose-dependent mode. Furthermore, LSPCs had significant (P < 0.05) stimulatory effects on mouse splenocyte proliferation. The prevention of tumour growth was exerted through diverse mechanisms, including cell-cycle arrest, induction of tumour cell death by apoptosis and increase of Ca²⁺ ions, together with stimulation of antioxidant enzyme activities and immunomodulatory activities.

Original language	English
Pages (from-to)	84-91
Number of pages	8
Journal	Food Chemistry
Volume	122
Issue number	1
DOIs	https://doi.org/10.1016/j.foodchem.2010.02.020
State	Published - 1 Sep 2010
Externally published	Yes

Keywords

Anti-cancer activity
Apoptosis
Immunomodulatory activity
Lotus seedpod
Melanoma
Procyanidin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.foodchem.2010.02.020

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title = "Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro",

abstract = "Significant growth inhibition effects of procyanidins from lotus (Nelumbo nucifera Gaertn.) seedpod (LSPCs) on mouse melanoma B16 were found both in vivo and in vitro. In vivo treatment with LSPCs inhibited tumour growth in C57BL/6 J mice by 55.3% in terms of average tumour weight. LSPCs can significantly (P < 0.05) decrease lipid peroxidation (LPO) levels and increase the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in liver tissue. In vitro assay of anti-cancer activities suggested that LSPCs (25-100 μg/ml) possessed cytotoxicities against mouse melanoma B16 in a dose-dependent mode. Furthermore, LSPCs had significant (P < 0.05) stimulatory effects on mouse splenocyte proliferation. The prevention of tumour growth was exerted through diverse mechanisms, including cell-cycle arrest, induction of tumour cell death by apoptosis and increase of Ca2+ ions, together with stimulation of antioxidant enzyme activities and immunomodulatory activities.",

keywords = "Anti-cancer activity, Apoptosis, Immunomodulatory activity, Lotus seedpod, Melanoma, Procyanidin",

author = "Yuqing Duan and Haihui Zhang and Feifei Xu and Bijun Xie and Xianwen Yang and Yong Wang and Yongsheng Yan",

year = "2010",

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doi = "10.1016/j.foodchem.2010.02.020",

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volume = "122",

pages = "84--91",

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T1 - Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro

AU - Duan, Yuqing

AU - Zhang, Haihui

AU - Xu, Feifei

AU - Xie, Bijun

AU - Yang, Xianwen

AU - Wang, Yong

AU - Yan, Yongsheng

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Significant growth inhibition effects of procyanidins from lotus (Nelumbo nucifera Gaertn.) seedpod (LSPCs) on mouse melanoma B16 were found both in vivo and in vitro. In vivo treatment with LSPCs inhibited tumour growth in C57BL/6 J mice by 55.3% in terms of average tumour weight. LSPCs can significantly (P < 0.05) decrease lipid peroxidation (LPO) levels and increase the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in liver tissue. In vitro assay of anti-cancer activities suggested that LSPCs (25-100 μg/ml) possessed cytotoxicities against mouse melanoma B16 in a dose-dependent mode. Furthermore, LSPCs had significant (P < 0.05) stimulatory effects on mouse splenocyte proliferation. The prevention of tumour growth was exerted through diverse mechanisms, including cell-cycle arrest, induction of tumour cell death by apoptosis and increase of Ca2+ ions, together with stimulation of antioxidant enzyme activities and immunomodulatory activities.

AB - Significant growth inhibition effects of procyanidins from lotus (Nelumbo nucifera Gaertn.) seedpod (LSPCs) on mouse melanoma B16 were found both in vivo and in vitro. In vivo treatment with LSPCs inhibited tumour growth in C57BL/6 J mice by 55.3% in terms of average tumour weight. LSPCs can significantly (P < 0.05) decrease lipid peroxidation (LPO) levels and increase the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in liver tissue. In vitro assay of anti-cancer activities suggested that LSPCs (25-100 μg/ml) possessed cytotoxicities against mouse melanoma B16 in a dose-dependent mode. Furthermore, LSPCs had significant (P < 0.05) stimulatory effects on mouse splenocyte proliferation. The prevention of tumour growth was exerted through diverse mechanisms, including cell-cycle arrest, induction of tumour cell death by apoptosis and increase of Ca2+ ions, together with stimulation of antioxidant enzyme activities and immunomodulatory activities.

KW - Anti-cancer activity

KW - Apoptosis

KW - Immunomodulatory activity

KW - Lotus seedpod

KW - Melanoma

KW - Procyanidin

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U2 - 10.1016/j.foodchem.2010.02.020

DO - 10.1016/j.foodchem.2010.02.020

M3 - 文章

AN - SCOPUS:77950596120

SN - 0308-8146

VL - 122

SP - 84

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JO - Food Chemistry

JF - Food Chemistry

IS - 1

ER -

Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro

Abstract

Keywords

UN SDGs

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