TY - JOUR
T1 - Influence of non-Gaussian noise on a tumor growth system under immune surveillance
AU - Du, Lin
AU - Guo, Qin
AU - Sun, Zhongkui
N1 - Publisher Copyright:
© 2018, EDP Sciences and Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - In this paper, the stationary probability distribution (SPD) function and the mean first passage time (MFPT) are investigated in a tumor growth model driven by non-Gaussian noise which is introduced to mimic random fluctuations in the levels of the immune system. Results demonstrate the different transitions induced by the strength of non-Gaussian noise under different immune coefficients and the dual roles of non-Gaussian noise in promoting host protection against cancer and in facilitating tumor escape from immune destruction. Additionally, it can be discovered that increases in noise strength, the degree of departure from Gaussian noise, and the immune coefficient can accelerate the extinction of tumor cells. Numerical simulations are performed, and their results present good agreement with the theoretical results.
AB - In this paper, the stationary probability distribution (SPD) function and the mean first passage time (MFPT) are investigated in a tumor growth model driven by non-Gaussian noise which is introduced to mimic random fluctuations in the levels of the immune system. Results demonstrate the different transitions induced by the strength of non-Gaussian noise under different immune coefficients and the dual roles of non-Gaussian noise in promoting host protection against cancer and in facilitating tumor escape from immune destruction. Additionally, it can be discovered that increases in noise strength, the degree of departure from Gaussian noise, and the immune coefficient can accelerate the extinction of tumor cells. Numerical simulations are performed, and their results present good agreement with the theoretical results.
UR - http://www.scopus.com/inward/record.url?scp=85055100402&partnerID=8YFLogxK
U2 - 10.1140/epjst/e2018-700136-8
DO - 10.1140/epjst/e2018-700136-8
M3 - 文章
AN - SCOPUS:85055100402
SN - 1951-6355
VL - 227
SP - 895
EP - 905
JO - European Physical Journal: Special Topics
JF - European Physical Journal: Special Topics
IS - 7-9
ER -