In vitro and in vivo evaluation of hierarchical porous structure for osteogenic differentiation promotion

Lan Wang; Wanzhen Liu; Tian Bai; Wenhao Zhou; Hanyuan Liu; Sen Yu; Lian Zhou

doi:10.1016/j.matlet.2022.133388

In vitro and in vivo evaluation of hierarchical porous structure for osteogenic differentiation promotion

Lan Wang, Wanzhen Liu, Tian Bai, Wenhao Zhou, Hanyuan Liu, Sen Yu, Lian Zhou

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The hierarchical micro-nano porous structure in this study was prepared on the surface of Ti-3Zr-2Sn-3Mo-25Nb (TLM) titanium alloy by electrochemical dealloying process, in which the size of the micro-grooves was 2.42 ± 0.83 μm in length and 0.58 ± 0.12 μm in width, and the size of the nanopores was 14.6 ± 0.57 nm. The hierarchical porous structure was detected to significantly reduce the surface roughness and enhance wettability, which is beneficial for the adhesion and spreading of cells. Notably, the hierarchical porous structure remarkably up-regulated osteogenic differentiation and inhibited adipogenic differentiation. The relevant mechanism can be explained as micro-scale grooves induced cell morphology and then guided differentiation behavior. In addition, the hierarchical porous structure also increased the contact area between the bone and the implant, and induced more new bone formation.

Original language	English
Article number	133388
Journal	Materials Letters
Volume	330
DOIs	https://doi.org/10.1016/j.matlet.2022.133388
State	Published - 1 Jan 2023
Externally published	Yes

Keywords

Biomaterials
Differentiation behaviors
Hierarchical porous
Osseointegration
Surfaces

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10.1016/j.matlet.2022.133388

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title = "In vitro and in vivo evaluation of hierarchical porous structure for osteogenic differentiation promotion",

abstract = "The hierarchical micro-nano porous structure in this study was prepared on the surface of Ti-3Zr-2Sn-3Mo-25Nb (TLM) titanium alloy by electrochemical dealloying process, in which the size of the micro-grooves was 2.42 ± 0.83 μm in length and 0.58 ± 0.12 μm in width, and the size of the nanopores was 14.6 ± 0.57 nm. The hierarchical porous structure was detected to significantly reduce the surface roughness and enhance wettability, which is beneficial for the adhesion and spreading of cells. Notably, the hierarchical porous structure remarkably up-regulated osteogenic differentiation and inhibited adipogenic differentiation. The relevant mechanism can be explained as micro-scale grooves induced cell morphology and then guided differentiation behavior. In addition, the hierarchical porous structure also increased the contact area between the bone and the implant, and induced more new bone formation.",

keywords = "Biomaterials, Differentiation behaviors, Hierarchical porous, Osseointegration, Surfaces",

author = "Lan Wang and Wanzhen Liu and Tian Bai and Wenhao Zhou and Hanyuan Liu and Sen Yu and Lian Zhou",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2023",

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day = "1",

doi = "10.1016/j.matlet.2022.133388",

language = "英语",

volume = "330",

journal = "Materials Letters",

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TY - JOUR

T1 - In vitro and in vivo evaluation of hierarchical porous structure for osteogenic differentiation promotion

AU - Wang, Lan

AU - Liu, Wanzhen

AU - Bai, Tian

AU - Zhou, Wenhao

AU - Liu, Hanyuan

AU - Yu, Sen

AU - Zhou, Lian

PY - 2023/1/1

Y1 - 2023/1/1

N2 - The hierarchical micro-nano porous structure in this study was prepared on the surface of Ti-3Zr-2Sn-3Mo-25Nb (TLM) titanium alloy by electrochemical dealloying process, in which the size of the micro-grooves was 2.42 ± 0.83 μm in length and 0.58 ± 0.12 μm in width, and the size of the nanopores was 14.6 ± 0.57 nm. The hierarchical porous structure was detected to significantly reduce the surface roughness and enhance wettability, which is beneficial for the adhesion and spreading of cells. Notably, the hierarchical porous structure remarkably up-regulated osteogenic differentiation and inhibited adipogenic differentiation. The relevant mechanism can be explained as micro-scale grooves induced cell morphology and then guided differentiation behavior. In addition, the hierarchical porous structure also increased the contact area between the bone and the implant, and induced more new bone formation.

AB - The hierarchical micro-nano porous structure in this study was prepared on the surface of Ti-3Zr-2Sn-3Mo-25Nb (TLM) titanium alloy by electrochemical dealloying process, in which the size of the micro-grooves was 2.42 ± 0.83 μm in length and 0.58 ± 0.12 μm in width, and the size of the nanopores was 14.6 ± 0.57 nm. The hierarchical porous structure was detected to significantly reduce the surface roughness and enhance wettability, which is beneficial for the adhesion and spreading of cells. Notably, the hierarchical porous structure remarkably up-regulated osteogenic differentiation and inhibited adipogenic differentiation. The relevant mechanism can be explained as micro-scale grooves induced cell morphology and then guided differentiation behavior. In addition, the hierarchical porous structure also increased the contact area between the bone and the implant, and induced more new bone formation.

KW - Biomaterials

KW - Differentiation behaviors

KW - Hierarchical porous

KW - Osseointegration

KW - Surfaces

UR - http://www.scopus.com/inward/record.url?scp=85140914050&partnerID=8YFLogxK

U2 - 10.1016/j.matlet.2022.133388

DO - 10.1016/j.matlet.2022.133388

M3 - 文章

AN - SCOPUS:85140914050

SN - 0167-577X

VL - 330

JO - Materials Letters

JF - Materials Letters

M1 - 133388

ER -

In vitro and in vivo evaluation of hierarchical porous structure for osteogenic differentiation promotion

Abstract

Keywords

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