Impact of dietary compounds on cancer-related gut microbiota and microRNA

Muhammad Shahid Riaz Rajoka, Mingliang Jin, Zhao Haobin, Qi Li, Dongyan Shao, Qingsheng Huang, Junling Shi

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Cancer is one of the most common causes of death worldwide. Extensive research has been conducted on cancer; regardless, the link between cancer and diet remains undetermined. Recent studies have emphasized the importance of miRNAs in cancer-associated pathways from the perspective of dietary modulation. We highlighted the recent data on dietary modulation of gut microbiota and miRNAs related to cancer on the basis of recently published results. The targets of miRNAs are oncogenes or tumor suppressors that mediate the progression and initiation of carcinogenesis. Different miRNAs display complex expression profiles in response to dietary manipulation. Various dietary components, such as fatty acids, resveratrol, isothiocyanate, and curcumin, have been effectively used in cancer prevention and treatment. This potency is attributed to the capability of these components to alter miRNA expression, thereby modulating the vital pathways involved in metastasis, invasion, apoptosis, tumor growth, and cell proliferation.

Original languageEnglish
Pages (from-to)4291-4303
Number of pages13
JournalApplied Microbiology and Biotechnology
Volume102
Issue number10
DOIs
StatePublished - 1 May 2018

Keywords

  • Autoimmune disease
  • Cancer
  • Diet
  • Microbiota
  • miRNAs

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