Identifying functional evolution processes of cancer according to regression residuals network

Bolin Cheny, Manting Yang, Xuequn Shang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The occurrence and development of cancer is a complex biological process, which usually requires further research by constructing a network. The existing methods of constructing networks are usually based on similarity to construct co-expression networks for analysis, but this similarity-based method usually ignores the data whose expression level increases or decreases at the same time in different groups. Gene pairs may also be related to the evolution of cancer, and that may cause part of the information to be lost. Therefore, we propose a new method of constructing a network based on regression residuals. Then, the module is identified based on the regression residual network according to different stages of cancer. A module network between cancer stages is obtained through the similarity between the modules. Finally, based on the size and density of the subnets in the modular network, enjoy the screening, and finally selected 3 subnets for functional analysis and Veen diagram analysis, and found some biological functions and genes that have been confirmed to be related to cancer.

Original languageEnglish
Title of host publicationProceedings - 2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021
EditorsYufei Huang, Lukasz Kurgan, Feng Luo, Xiaohua Tony Hu, Yidong Chen, Edward Dougherty, Andrzej Kloczkowski, Yaohang Li
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3713-3719
Number of pages7
ISBN (Electronic)9781665401265
DOIs
StatePublished - 2021
Event2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021 - Virtual, Online, United States
Duration: 9 Dec 202112 Dec 2021

Publication series

NameProceedings - 2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021

Conference

Conference2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021
Country/TerritoryUnited States
CityVirtual, Online
Period9/12/2112/12/21

Keywords

  • biological functions
  • co-expression networks
  • module network
  • regression residual

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